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14 Cards in this Set

  • Front
  • Back
Alzheimer's Disesase
-->Amyloid-β protein misfolding
Lou Gehrig's Disease
-->misfolded SUPEROXIDE DIMUTASE

O2- ------> H2O2 (rxn blocked)
Type II Diabetes
-->misfolded Islet Amyloid Polypeptide
Transmittable Spongiform Encephalitis
Mad Cow's Disease
-->misfolded PRION
Huntington's Disease
-->Huntingtin w/ POLYGLUTAMINE EXPANSION

-->expansion of the variable number tandem repeats within the gene (microsatellites)

--> more than 30 CAG repeats
Hereditary Persistance of Fetal Hemoglobin
-->mutation in DNA

-->triple helix cannot form to inhibit y-globulin gene promoter

-->similar in symptoms to β-thalessemia
Tetracyclines
-->bind to the 30S subunit of prokaryotic ribosomes

-->prevent attachment of aminoacyl tRNA synthase
Streptomycin
-->targets the formation of FORMYL- tRNA (Methionine)

-->only prokaryotes use formyl-tRNA (Met)
Quinolones
Nalidixic Acid
-->inhibits GYRASE activity

-->prevents resealing of dsDNA breaks
Cisplatin
-->platinum-based chemotherapy

-->induces dsDNA crosslinking

-->apoptosis
Ciporoflaxin
-->fluoroquinolone

-->topoisomerase inhibitor

-->prevents dsDNA re-ligation

(also, nalidixic acid for gyrase)
Lamivudine
-->nucleoside analog effective agains HBV and HIV

-->chain-terminator

-->analong for CYTIDINE
Azidodeoxythymidine
AZT

-->nucleoside analog for THYMIDINE
Efavirenz
-->nonucleoside RT inhibitor

-->binds to RT and sterically hinders