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10 Cards in this Set
- Front
- Back
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A patient presents with paroxysmal cough, whoop, and post tussive vomiting, what bacteria would you suspect in the infection?
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Bordetella species
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What are the differences between the WHO and the CDC guidelines in the clinical diagnosis of pertussis?
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Epidemiologic and clinical criteria of paraoxysmal cough for 14 (CDC) or 21 (WHO) days are used for making the clinical diagnosis
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Who are reservoirs for pertussis?
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Adults and adolescents are an important reservoir and are often a source of infection for infants
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Describe B. pertussis.
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They are small nonmotile, aerobic Gram negative rods.
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How does pertussis attach to the respiratory epithelium?
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A protein on the pili, called filamentous hemagglutinin mediates attachment
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How does pertussis prevent the cilia from sweeping it out of the respiratory tract
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These bacteria make toxins that paralyze the cilia
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What is the vaccine that is given to provide immunization against B pertussis?
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Acellular pertussis vaccine in combo with diphtheria and tetanus toxoids (DTaP)
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Who should be immunized with DTaP?
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children aged 6 weeks to 6 years
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How does the pertussis toxin affect the cell?
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Pertussis toxin irreversibly inactivates the G i -protein complex via ADP ribosylation. This results in prolonged stimulation of adenyl cyclase and a consequent rise in cAMP.
Elevated cAMP levels increase cellular protein kinase activity |
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How does pertussis kill ciliated cells?
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With a peptidoglycan fragment that kills ciliated cells
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