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38 Cards in this Set
- Front
- Back
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Describe the characteristics of HAV (DNA/RNA, +/-, etc)
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Small, Single Stranded RNA Hepatovirus. Positive Polarity. Icosahedral, No Lipid Envelope
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Describe the characteristics of HBV (DNA/RNA, +/-, etc)
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Double Shelled DNA Hepadnavirus. 3.2kb circular, incomplete dsDNA. Larger particles are full assembly infectious virus particles with a lipid envelope. Smaller particles are a spherical nucleocapsid core and tubular or filamentous particles of surface proteins.
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Describe the characteristics of HCV (DNA/RNA, +/-, etc)
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Enveloped Flavivirus, icosahedral capsid, single stranded, positive sense RNA.
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HAV Ab to dx acute infection
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HAV IgM
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HBV Ab to dx acute infection
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1st = HBsAg. Next = IgM HBcAb, HBeAg
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HCV Ab to dx acute infection
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HCV RNA (PCR), HCV Ab
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HAV Protective Ab
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IgG HAV Ab
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HBV Protective Ab
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IgG HBsAb
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HCV Protective Ab
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None
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HAV route of transmission
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Fecal Oral
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HBV route of transmission
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IV Drugs, Sex, Maternal (vertical)
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HCV route of transmission
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IV drugs, needles, transfusion, organ transplant, sex is possible but not usual
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Mechanism of liver damage in Hepatitis
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Cytotoxic T cells destroy virus infected hepatocytes
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Only hepatitis virus that can be cultivated in cell cultures
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HAV
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Food linked to HAV outbreaks
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Shellfish
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Populations at risk for HAV
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Children at Day Care, Prisoners
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Hepatitis with shortest incubation
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HAV
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IgM HAV Ab is detectable when
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5-10 days before onset of sx
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Hepatitis with NO CHRONIC STATE
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HAV
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HAV Tx
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Supportive, Ig given < 2wks after exposure can help, Killed Vaccine has 10-30yr protection
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Primary component of HBV vaccine
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HBsAg
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Things contained in inner core of HBV
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HBcAg, HBeAg, 1 molecule of partially dsDNA, DNA dependent DNA polymerase with reverse transcription function
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Hepatitis with slow, insidious onset
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HBV
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HBsAG can be detected as early as ______ and as late as ______
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1-2 wks, 11-12 wks after exposure
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HBsAG no longer detecable after
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3 mos
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IgM HBcAb becomes undetectable after
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6 mos
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Marker of past HBV infection
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IgG HBcAb
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Markers of Chronic HBV infection
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HBsAg, IgG HBcAb (w HBeAg = infectious)
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Hepatitis associated with increased risk of Hepatocellular Carcinoma
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HBV
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Tx of acute HBV
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Supportive
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Tx of chronic HBV
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interferon-alpha, Lamivudine, Adefovir
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Type of Hepatitis with many different strains
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HCV
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Term for different HCV species
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Quasi-species
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Clinical significance of different HCV strains
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Infection with one HCV subtype does not protect against others
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HCV tx
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Support, Interferon, Ribavirin
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Is there a vaccine for HCV
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No HCV Vaccine
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HBV labs most likely to show
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Lymphocytic Leukocytosis, inc ALT, AST, Bilirubin
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Pt has had jaundice, etc for 1 week. Had sex with prostitute in Thailand 6 months before. What serum marker would be positive
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IgM HBc Ab
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