Naplex-Asthma/copd

Front 1

What are the main cells associated with Asthma

Back 1

Esosinophils (IGE) allergies

Front 2

What are the main cells associated with COPD

Back 2

Neutrophils

Front 3

Asthma is described as airway hyperreactivity, and what medications do they response to

Back 3

Broncodialtors, and Inhaled corticosteriods

Front 4

COPD has NO airway hypereativity thus it does not respond well to

Back 4

bronchodialtors and inhaled crotciosteriods

Front 5

Peak flow zones are only used in what patients

Back 5

Asthma patients

Front 6

Peak Flow Zones, are divided in Green Zone, Yellow Zone, and Red Zone, are based on a percentage of what

Back 6

personal best (Green 80-100% of personal best)

Front 7

What are 3 types of Asthma

Back 7

Allergic
Exercise induced
Norcturnal

Front 8

What is MOA Of Beta 2 Agoinsts

Back 8

Increase CAMP (which decreases Ca+) and causes smooth muscle relaxation

Front 9

What is age children can first use Pirbuterol (MaxAir)

Back 9

12 or olders

Front 10

What are oral options for Short Acting B2 agoinsts (no choosen bc of systemic effects and shorter acting)

Back 10

Albuterol syrup, and tablets, also metaproteronol, and terbutaline

Front 11

What oral Beta 2 agoinsts have FDA indications for COPD

Back 11

Metaproternol (syrup) and Terbutaline tablets

Front 12

What are the long-acting Beta 2 Agoinsts

Back 12

Formoterol, Salmeterol, Albuterol ER tabs,

Front 13

Should the LABA ever be used ALONE in Asthma

Back 13

NO--


Can use alone in COPD

Front 14

What are the common side effects of Beta 2 agonists

Back 14

Tremor, increase HR, and Hypokalemia--for oral

Front 15

What is Xopenex (Levalbuterol)

Back 15

R-albuterol isomer or activity

NO BENEFITS

Front 16

LABA should only be used for the shortest duration possible and tapered off, and why must it always occur with other medications

Back 16

LABAs can increase risk of asthma related death

Front 17

What are available combination steriods/LABAs

Back 17

Advair (fluticasone/salmeterol)
Symbicort (budesonide/formoterol)
Dulera (mometasone/formoterol)

Front 18

What is time to maximal benefit with inhaled corticosteriods, and should always counsel on

Back 18

varies 2-3 weeks, rinse and spit mouth after use

Front 19

What are the mast cell stabilizers

Back 19

Cromoyln and Nedocromil

Front 20

Can the mast cell stabilizers be used for acute exacerbations

Back 20

NO

Front 21

How long to mast cell stabilizers take to wrok

Back 21

2-4 weeks to be effetive

Front 22

What are the Lueukotriene Receptor Antagoinsts

Back 22

Montelukast (singular)
Zafirlukast (Accolate)

Front 23

What is the 5-Lipooxygenase Inhibitor

Back 23

Zileuton

Front 24

Are the Leukotreine modifers used for acute attacks

Back 24

NO

may be used in some exercise induced attacks

Front 25

What is MOA oF Theophylline

Back 25

Phosphodiesterase inhibitor

Front 26

Theophylline is NARROW therapuetic drug, what is window (MUST KNOW)

Back 26

5-15 mcg/mL

Front 27

What are SE of Theophilline toxicity

Back 27

N/V, Insomnia, Tremors, HA, Confusion

Front 28

Theophylline has MANY drug interactions, what does smoking do

Back 28

decrease Theophylline levels

Front 29

What is MOA of Xolair (Omalizumab)

Back 29

inhibit the binding of IGE to mast cells and basophils

Front 30

What is role of Xolair

Back 30

moderate to severe allergic asthma not controlled well on other medications

Front 31

How is Xolair administered, and often

Back 31

SUBQ, dosed every 2-4 weeks

Front 32

What are potential benefits of IGE antibodies

Back 32

help reduce steriod use

Front 33

What is STEP 1 of Asthma

Back 33

SABA PRN

Front 34

What is STEP 2

Back 34

LOW dose ICS

or Luekotirene modifered
or cromoyln

Front 35

What is STEP 3

Back 35

MEDIUM DOSE ICS
or
LOW ICS +LABA

Front 36

What is STEP 4

Back 36

Medium Dose ICS + LABA

Front 37

What is STEP 5 (worse step)

Back 37

HIGH ICS + LABA + oral corticosteriod

Front 38

When should you consider stepping down in thearpy

Back 38

after 3 months of good control

Front 39

What is preferred treatment of children <6 years for asthma

Back 39

spacer with face mask or nebulizer with face mask

Front 40

COPD is a chronic disease characterized by what

Back 40

irreversible obsturction due to changes in lung tissue

Front 41

What is leading risk factor for COPD

Back 41

smoking

other less effects include occupations, and childhood illnesses

Front 42

What are the mainstay thearpy of COPD

Back 42

broncodialtors

Front 43

What are the broncodialtors

Back 43

B2 agoinsts
Anticholingerics

Front 44

What is MOA of Antichoinergic

Back 44

block the muscarinic receptor causing smooth muscle relaxation

Front 45

What are the SE of Anticholingerics

Back 45

Dry mouth, Dry eyes, and possible worsening of Narrow angle gluacoma

Front 46

Home oxygen is indicated for long-term therapy, and indicated with O2 stat <88%, and is their a mortaility benefit

Back 46

YES

Front 47

What drugs should be used in caution with COPD

Back 47

B-blcokers (non-selective), and respiratory depressants