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12 Cards in this Set
- Front
- Back
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Alpha Antagonists
Therapeutic uses |
-hypertension
-overdose -BPN -Pheochromocytoma -Raynaud’s disease |
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Alpha Antagonists
ADVERSE |
-Orthostatic hypotension
-reflex tachycardia -nasal congestion -inhibition of ejaculation -sodium retention & ↑blood volume -Alpha 2 blockade ?? |
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Phentolamine
Trade type |
Rogitine©
Alpha-Adrenergic Antagonists |
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Phentolamine
MOA |
- competitive alpha-adrenergic antagonist that blocks both types of α receptors
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Phentolamine
INDICATIONS |
- Pheochromocytoma
- prevention of tissue necrosis after extravasation |
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Phentolamine
ADVERSE |
- orthostatic hTN
- reflex tachycardia - nasal congestion - inhibition of ejaculation |
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Phentolamine
CAUTION |
-angina, or MI or hypertension
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Phentolamine
INTERACT |
- can antagonize vasoconstrictor and HTN effects of epi or ephedrine
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Beta Antagonists
Therapeutic uses |
-angina
-hypertension -arrhythmia’s -MI -heart failure -hyperthyroidism -migraine -stage fright -pheochromocytoma -glaucoma |
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Beta Antagonists
Drugs |
-Propranolol: 1st gen (nonspecific Block B1 & B2)→B1/B2 Blockade
-Metoprolol: 2nd gen (specific Block B1) → B1 Blockade -Labetalol:3rd gen →A1 blockade |
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Beta Antagonists
Adverse B1 Effect |
-bradycardia
-reduced cardiac output -precipitation of heart failure -AV heart block -rebound cardiac excitation |
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Beta Antagonists
Adverse B2 Effect |
-bronchoconstriction
-inhibition of glycogenolysis |
