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8 Cards in this Set

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Levodopa

trade
type
Dopar©

Dopaminergic Agents
Levodopa

MOA
- Promote dopamine synthesis
- Prevent dopamine breakdown
-prevent dopaminergic drug breakdown
- Promote dopamine release
- Direct activation of dopamine receptors

Are for symptom relief & no way curative
Levodopa

results in dyskinesias
• tremor at rest,
• rigidity,
• postural instability,
• bradykinesia
Levodopa

Levodopa
-most common drug treat PD, used for symptom relief, no way curative
-works: crossing BBB & entering dopamine terminals within striatum where is converted into dopamine
-much converted/broken down before leaves periphery, so given with Carbidopa
Levodopa

Carbidopa
inhibits conversion of Levodopa in periphery
Parkinson’s:
-characterized by dyskinesia’s related to imbalance between dopamine & acetylcholine in striatum of extrapyramidal system
-is degeneration of neurons that supply dopamine to striatum in substantia nigra
-↑acetylcholine → ↑GABA: →dyskinesia’s common in PD
Benztropine

Trade
type
Cogentin©

Anticholinergic Agents
Benztropine

MOA
other sruff
- Blockade of muscarinic receptors in striatum
-Not 1st line PD treatment , reserved for EPS treatment caused by antipsychotics
-reduce tremors & rigidity, not bradykinesia
-blocks cholinergic receptors in periphery, causing
*dry mouth
*blurred vision, photophobia
*urinary retention, constipation
*tachycardia