Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
List the 4 receptors involved with PONV.
|
serotonin
histamine muscarinic dopaminergic |
|
|
where is the N/V center located?
|
medulla
|
|
|
The nausea and vomiting center is composed of three different nuclei. Name them.
|
Nucleus solitarius
Nucleus of the vagus Nucleus ambiguus |
|
|
Which of the 3 nuclei involved in PONV is responsible for filtering afferent information from the body?
|
nucleus solitarius
|
|
|
Which of the 3 nuclei involved in PONV is responsible for vomiting?
|
Nucleus of the vagus
Nucleus ambiguus |
|
|
Where is the CTZ located?
|
area postrema in the floor of the fourth ventricle in the medulla
|
|
|
To what is the CTZ sensitive?
|
chemical stimulation from noxious agents from within the blood and cerebrospinal fluid
|
|
|
List some endogenous neuroactive peptides that can cause N/V.
|
vasopressin
angiotensin II neurotensin insulin gastrin oxytocin TRH |
|
|
What is Emend (Aprepitant)?
|
substance P/neurokinin I antagonist
used in combination with other antiemetics for highly emetogenic chemotherapy |
|
|
What is and where is the vestibular system?
|
it is the middle ear
remember CN VIII - vestibulocochlear nerve disturbances in this area can result in N/V |
|
|
What is the purpose of multimodal therapy for N/V?
|
It's aimed at targeting different areas of afferent input into the nucleus solitarius
|
|
|
Where are 5HT3 receptors located?
|
CTZ
nucleus solitarius GIT |
|
|
List risk factors for developing PONV
|
young
female non-smoker large body habitus Hx of PONV Hx of motion sickness type of surgery (eye, ear, laparoscopic abd) administration of opioids during procedure |
