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5 Cards in this Set
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What are the things that ulcerative colitis and chronns have in common?
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Age of onset is teens to mid-30s, diarrhea, abdominal cramping, Perforation (but for different reasons).
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How do the following clinical manifestations compare in each of the diseases in IBD?
Fever, Wt. Loss, Rectal Bleeding, Tenesmus, and Malabsorption/Nutrion deficencies? |
Fever: in UC during acute moderate and severe attacks; In chronns fever is a common occurrence; Weight loss: In UC happens in severe cases, but in chronns it is common and may be severe!; Rectal bleeding: In UC very common, but in Chroons-infrequent; Tenesmus (ineffectual, painful straining) in UC it is common, in Chronn's tenesmus is rare; Malabsorption/nutritional deficiency: Minimal incidence in UC, but in Chronn's it is common.
I sort of categorize that chronns of course will have malabsorption because look at the diarrhea, the weight loss... and with UC, of course there is blood in stool, they have tenesmus,. |
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Explain the following pathological differences between UC and Chronn's
Location, Distribution, Depth of Involvement, Granulomas (would show on a biopsy), Cobblestoning of mucosa, Pseudopolyps, Small Bowel Involvement. |
Location: in UC it starts in rectum and spreads in a continuous pattern up the colon, but in Chronns it occurs anywhere along GI tract skipping lesions and the most frequent site is the terminal ileum; Distribution: In UC it is continuous areas of inflammation, but in Chronns it is healthy tissue interdispersed with areas of inflammation or skip lesions; Depth of Involvement: Mucosa and submucosa in UC, but in Chronns it is the ENTIRE thickness of bowel wall (transmural); Granulomas: UC has occasional granulomas, but in Chronns it is common to have granulomas; Cobblestoning: in UC it is rare, but in Chronns it is common; Pseudopolyps: in UC common! , but in Chronns-rare! and Small bowel involvment: in UC minimal, usually backwash into ileum only, but in Chronns the small bowel is commonly involved
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Compare the following Complications in UC and Chronns:
Fistulas, Strictures, Anal abscesses, Perforation, Toxic Megacolon, Carcinoma, and Recurrence after surgery. |
Fistulas: In UC rare, in Chronns-common; Strictures: in UC sometimes, but in Chronns-common; Anal absesses: in UC rare, but in Chronns-common; Perforation: Common in UC d/t toxic megacolon, but in Chronns-common d/t inflammation that involves entire bowel wall transmurally; Toxic megacolon (rapid, painful dilation of colon) is common in UC, but rare in chronns; Carcinoma: Increased incidence after having UC for 10 years, but in chronns there is an increased chance in sm. colon, but not as common as with uc; Recurrence after surgery: Cure with colectomy, but with chronns recurrence can happen at the site of anastomosis.
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What are some extraiintestinal manifestations that can happen from IBD? Joints, skin, Circulation, Bones, mouth, eye, gi, gu?
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Joints: Peripheral arthritis (colitic), ankylosing spondylitis, Sacroiliitis, Finger clubbing; Skin: Erythema nodosu, pyoderma gangrenosum; Circulation: Thromboembolism; Mouth: Aphthous ulcers; Eye: Conjunctivitis, Uveitis, Episcleritis; GI: Gallstones, Liver disease (primary sclerosing cholangitis); GU: kidney stones; and Bone: Osteoporosis.
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