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15 Cards in this Set
- Front
- Back
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H2 receptor blocker |
- ECL release histamine that bind H2 receptor of parietal to activate cAMP pathway to proton pump - H2RA block this |
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antimuscarinic agents |
ACH bind M3 of parietal cell to activate Ca pathway to proton pump activation -antimuscarinic agents block this |
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prostaglandins |
PG bind EP3 at epithelial cell to produce mucus and bicarbonate and bind at EP3 on parietal to inhibit cAMP process of proton pump activation |
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misoprostol |
analogue of PGE2 SE: diarrhea, cramping, abortifacient |
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octreotide |
G cells release gastrin that bind CCK2 on ECL to release histamine or bind CCK2 on parietal cell for pump activation --> D cells release somastatin that inhibit gastrin release - octreotide act like somatostatin |
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antacids |
Al (constipation), Mg (laxative), HCO3 (flatulence), Ca (nothing) |
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lubiprostone |
PGE1 analogue that activates Cl channels so Cl enters followed by water to cause severe and long lasting diarrhea |
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peristalsis and the receptors |
-5HT3 agonist inhibit ACh release - inhibit contraction - 5HT3 antagonist allow ACh release - contraction occur -5HT4 agonist stim release of ACh - contraction - D2 antagonist - increase peristalsis |
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cisapride |
5HT4 agonist - good prokinetic, QT elongation |
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erythromycin |
resemble motillin that promote peristalsis |
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colchicine |
-MOA: dec microtubular formation to prevent chemotaxis of inflamm cells - good diagnostic agent - 1.2 mg po then 0.6 mg 2 hrs later - SE: gastritis, CNS paralysis, blood dycrasias, fatal at 7 mg |
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probenacid |
-uricosuric agent - compete w/uric acid for renal reabsorption - prevent reabsorption of UA causing increase urinary excretion of UA SE: kidney stone, hypersensitivity |
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allopurinol |
- Xo inhibitor - competitive inhibitor w/xanthine for converion to UA - metabolized to alloxanthine - SE: hypersensitivity, acute flares (dec UA levels cause tophi to dump UA back into system) |
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rasburicase |
recombinant uricase SE: blood dyscrasia, renal failure, anaphylaxis, n/v, HA |
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pegloticase |
peglyated uricase - less immunologic - SE: acute flair, infusion rxn, anaphylaxis, n/v, constipation |
