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11 Cards in this Set
- Front
- Back
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What is the tx of choice for delirium due to benzo or EtOH withdrawal?
- what may they worsen? - side effects? - contraindicated when delirium is due to ______. |
benzodiazepines
- confusion - behavioral disinhibition, amnesia, ataxia, respiratory depression - hepatic encephalopathy |
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L-DOPA when used in conjunction with what can cause a hypertensive crisis?
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MAOI (type A)
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What does Monoamine oxidase type B do?
- What drugs block it selectively? - which is more potent? - which is metabolized into amphetamine? |
metabolizes dopamine
selegiline & rasagiline rasagiline (5x) selegiline |
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What does catechol-O-methyl tranferase do?
- examples of this class? - is the majority of their effect central or peripheral? - which is associated with fulminating hepatic necrosis? |
metabolizes L-DOPA... only is a minor pathway until peripheral dopamine decarboxylase is blocked by carbidopa.
- entacapone, tolcapone - peripheral - tolcapone |
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What is bromocriptine?
- side effects? |
dopamine-receptor agonist (D2), and is an ergot derivative can cause pulmonary/retroperitoneal fibrosis.
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What are some non-ergot D2 receptor agonists?
Do any of the D2 receptor agonists work in pts that don't respond to L-dopa? Which is hugely dependent on renal clearance? |
ropinirole, pramipexole, and rotigotine.
no. pramipexole |
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Fluroquinolones and other CYP450 inhib interfere w/ metabolism of which D2 receptor agonist?
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ropinirole
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What antiviral, typically used from tx of influenza, is used to tx parkinson's dz?
- primary effect? - other effects? |
amantadine
- inhibits NMDA - Increases dopamine release, blockades cholinergic receptors |
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Do antimuscarnic's play a large role in tx of Parkinson's dz?
- why might they help? - examples? |
no, only adjuvant.
- Blcok muscarinic receptors in the CNS, which helps adjust the dopamine/ACh imbalance that is the main biochemical source of parkinson's sx. - benztropine, trihexyphenidyl, procyclidine, biperiden |
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What drugs are used to tx Alzheimer's dz?
- examples? - which is the only that doesn't use the P450 pathway? |
Acetylcholinesterase inhibitors
- donepezil, galantamine, rivasigmine, tacrine. - rivastigmine |
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What is memantine?
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dimethyl adamantine derivative that physically blocks the NMDA receptor-associated ion channel.
- Possibly neuroprotective |
