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3 Cards in this Set
- Front
- Back
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Accelerated phase of CML
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increase count
splenomegaly increased left shift intensive therapy increased blasts but < 20% |
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Imatinib
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Use: treatment of CML
MOA: works by competing with ATP for binding to kinase catlytic domain SFx: edema (70%), nausea (70%) & vomiting (54%), diarrhea (50%), cramps (46%), myelosuppression (30%), possibly cardiotoxicity Resistance: point mutation in Abl kinase domain (T315l). Overproduction of BCR-ABL |
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Treatment of CML
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imatinib
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