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10 Cards in this Set
- Front
- Back
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What are myeloproliferative disorders?
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Diseases involving the bone marrow and production of blood
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What are the 3 common disorders?
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Polycythaemia rubra vera
Myelofibrosis Thrombocythaemia (essential/primary) (Leukaemias can also be put in this group) |
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What is polycythaemia rubra vera?
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Malignant proliferation of bone marrow:
Increase in all cell types leading to hyperviscosity |
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Symptoms polycythaemia rubra vera? (8)
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Facial plethora
Pruritis Epistaxis Cerbral vascular accidents Coronary events Visual disturbances Tinnitus and dizziness Headaches |
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Rx PRV (4)
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Venesection
Hydroxycarbamide IFN alpha Aspirin |
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What is Myelofibrosis?
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Malignant proliferation of bone marrow, due to release of growth factor from megakaryocytes (produce platelets) leading to fibrosis. As a result there is extramedullary haematopoeisis (e.g. in the spleen)
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Symptoms myelofibrosis? 3
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Abdo pain due to splenic infarcts
Distended abdo due to massive splenomegaly Symptoms of anaemia |
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What is Primary/essential thrombocytosis?
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Increase in production of platelets
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Symptoms thrombocythaemia? 2
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Acute bleeding
Vascular occlusion - coronary, cerbrovascular accidents |
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Prognosis thromcythaemia? (2)
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Myelofibrosis
Acute leukaemia |
