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12 Cards in this Set
- Front
- Back
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Myeloid failed hematopoisis
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AML
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Myeloid under-production
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Myelodysplasias
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Excess myeloid production
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Myeloproliferative disorders
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Myeloproliferative neoplasms (MPN)
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CML
Polycythemia vera (PV) Essential thrombocytosis (ET) Primary Myelofibrosis (PMF) |
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General Features of CMPD
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afebrile, splenomegaly
WBC variable may be >100 circulating blasts, inc basos hypercellular BM clonal |
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CML
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t(9;22) - CC, FISH, PCR
BCR/ABL Non-receptor tyrosine kinase activation Tyrosine Kinase blocker (Imatinib) |
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PV
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Erythropoietin independent erythropoiesis
Mutation of JAK2 kinase Increased Hb and hematocrit Exclude other MPN Supress marrow; hydroxyurea |
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ET
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MPD emphasizing thrombocytosis
TPO independent platelet production Platelets >450 JAK2+; t(9;22)- |
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PMF
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BM fibrosis with extramedullary hematopoiesis
Splenomegaly JAK2 |
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What is MDS
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Ineffective hematopoiesis
Ineffective and disordered maturation Abnormal cells stay in BM -->cytopenia Symptoms due to pancytopenia |
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Subtypes of of MDS
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primary - idiopathic
secondary to previous drug or radiation therapy (t-MDS) |
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t-MDS
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appears 2-8 yrs after exposure
highest frequency and most rapidly transforms to AML |
