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18 Cards in this Set
- Front
- Back
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What does MDS frequently progress to?
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Acute myelogenous leukemia (AML)
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MDS lab findings?
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Macrocytic anemia
Decreased reticulocyte count Neutropenia Thrombocytopenia (tear drop RBC) Bone marrow: ringed sideroblasts, myeloblasts less than 20% |
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What chromosomes are sequentially mutated in MDS?
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Chroms 5,7,8, 20
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AML mostly in children or adults?
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adults
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What leukemia is associated with DIC and gingival infiltrate?
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AML
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What inherited disorders are associated with AML?
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Fanconi's anemia
Down syndrome |
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What type of AML has Auer rods cells?
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Acute promyelocytic leukemia
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In which type of AML is DIC very common?
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Acute promyelocytic leukemia (see Auer rods cells) t(15;17)
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Tx of acute promyelocytic leukemia?
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Treat with all-trans retinoic acid
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What type of leukemia is associated iwth hyperdiploidy and TEL-AML1 (t12;21)?
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acute lymphoblastic leukemia
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Which abnormalities are associated iwth a poor prognosis in ALL?
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t(9;22) BCR-ABL
t(4;11) MLL-AF4 t(8;14) hypodiploidy |
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CNS invovlement is more common in ALL than AML, but what subtype of AML is the exception?
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M5 (monocytic) subtype in AML have 25-30% CNS involvement
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Clinical features of CLL?
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elderly greater than 50yo
Often asymptomatic May present iwth LAD or SM Autoimmune phenomena may occur May be associated with decreased levels of IGs |
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CLL: chronic lymphoid leukemia
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Population of B lymphocytes with:
CD5+, CD19+, CD20+, CD23+, slg+ with light chain restriction |
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What is the main concern for CLL?
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infections
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What is Richter's transformation?
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Transformation to an aggressive non-Hodgkin's lymphoma in CLL
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CD10 and TdT positive, what type of cancer?
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Acute lymphoblastic leukemia (ALL)
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t(12;21) in ALL, good prognosis or no?
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good
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