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30 Cards in this Set
- Front
- Back
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pleomoprhic, no cell wall, no gram stain, not suceptible to beta lactam antibiotics, "fried egg", only membrane that contains cholesterol
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Mycoplasma
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Causes pneumonia, brinchitis, pharyngitis, croup
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Mycoplasma pneumoniae
- tetracycline and erythromycin |
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causes cervicits, post partum spesis, neonatal infection
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Mycoplasma hominis
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T strain mycoplasmas, small on solid medium,
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Ureaplasma
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NGU, upper genital tract infections, neonatal infections
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Ureaplasma urealyticum
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Virulence factors of Mycoplasma
P1 P50,P100 p140 Phospholipases A1, A2, C |
P1 - Adhesion protein in M. pneumoniae
P50.P100 - two adhesion proteins in M. hominis P140 - adhesion protein in M. genitalium Phospholipases - plasma membrane of U. urealyticum, hydrolyzes phospholipids |
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M. penumoniae causes ____ ____
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walking pneumonia (atypical pneumonia) only 3 - 10 % of people exposed get pneumonia, rest get bronchitis
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PAthogenesis of M. pneumoniae
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Attachment to epithelial respiratory cells, necrosis.
2-3 week incubation Fever 103, chills, sore throat, nasal congestion, dry nonproductive cough |
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Treatment of M. pneumoniae
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tetracycline and erythromycin
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Lab Identification of M. pneumoniae
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Detct its ability to produce acid from glucose, methylene blue-glucose diphasic medium.
Subculture to glucose agar medium, then tetrazolium redcution test |
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Responsible for amniotic infections, intense inflammatory response
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Ureaplasma urealyticum
- associated with per-eclampsia |
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Isolated from respiratory and genital tracts, smallest genome capable ofselfreplication, protein P140
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Mycoplasma genitalium
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Isolation of M. hominis and U. urealyticum
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urethral/vaginal/cervical swabs
M broth and agar, U broth and agar |
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Synthetic species of bacterium, hopee to use to manufacture hydrogen and biofuels
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Mycoplasma laboratorium
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Gram - rods, stain poorly, grow at 35 C, nonspore, motile single fag, aerobic, slender rods, binary fission, gel +, cat +, no3 Red - , urea -,
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Genera Legionella
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LEgionella use ____ for growth
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Amino acids
- do no ferment or oxidize carbohydrates grow on BCYEa |
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Form of pneuomina, 2 - 10 day incubation period.
First day: dry cough, 102-104 Fever and chills, abdomi pain |
Legionellosis
includes legionaire's disease and POntiac Fever |
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Who is predisposed to Legionellosis
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55 + yrs, immunosupressed patients, diabtes, smokers, alcoholics
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Pathogenesis of LEgionella
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L. pneumophila
intracellular parasites, adhesions, DNase, lipase, phosphatase, proteolytic enzymes. Replicates in alveolar macrophages, inhibit phagolysosome fusion and acidification of the phagosome MP, macrophae invasion protein Phospholipase C (hydro phosphatidylcholine) Zinc metalloprotease |
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Lab ID of Legionella
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flurorescent antiobody method, nucleic acid probe
Gold Standard: BCYEa (add polymyxin inhib. G-; anisomycin inhib. yeast; vancomycin inhib. G+) |
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Treatment of LEgionella
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Erythromycin with rifampin
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Prevention and Control of LEgionella
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Chlorine (2ppm) in cooling towers
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Milder Legionella disease, aerosol, incubation 1-2 days.
Mild fever, chills, headache, myalgia, respiratory disease w/out pneumonia |
Pontiac Fever Syndrome
Legionella micdadei |
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small G- rods, facul anaerobe, nonmot, nonspore, cat +, oxi +, requires growth factors X and V
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Family Pasteurellaceae
Genus Haemophilus |
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Causes ear infections, pneumonia, and meningitis
Requires growth factors X and V |
Haemophilus influenzae
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causes chancroid or soft chancre, requires factor X
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Haemophilus ducreyi
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causes pink eye, infection of the conjuctiva, requires factor X and V
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Haemophilus aegyptius
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normal flora of the Upper respiratory Tractm requires factor V
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Haemophilus parainfluenzae
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One of the leading cause of bacterial meningitis, capsule, most infections caused by B strain, pili for adherence and hemagglutinations, IgA protease, bacteriocin, and LPS
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Haemophilus influenzae
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Lab identification of HAemophilus
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Choco agar, sheep's RBC heated to lyse RBC and release factors X and V
H/influenzae colorless H.parainfluenzae yellow colonies |
