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15 Cards in this Set

  • Front
  • Back
cholinergic agonists' effects on cardiovascular effect
blood vessels- what receptor
Blood vessels- M3
circulating ACH act on M3R in vascular endo- release NO
decrease TPR, BP
tachycardia due to baroreflex
vasoconstriction due to direct effects on vascular sm
cholinergic agonists' effect on Heart, what receptor
Heart- M2
SA: decreased pacemaker current/ increased repolarizing current
decreased HR, SA-AV nodal conduction velocity
atrial muscle, decreased atrial contractility
SN terminals (M2) presynaptic-heteroreceptor, inhibiting NE release
cholinergic agonists

effects on respiratory system
PS ganglion neurons

Bronchial sm

PSN ending
PS ganglion neurons (M1)
stimulate ACH release
bronchoconstriction and secretion

bronchial sm (M2/M3)

M3-contraction of sm directly
bronchoconstriction

bronchial glands: M3, increase secretions

PSN ending M2: presynaptic autoreceptor, inhibit ACH release, reduce bronchoconstriction/secretion
urinary system

bladder sm

detrusor mus/sphincter
Bladder sm (M2/M3)

contraction of detrusor m/relaxation of sphincter

voiding
GI

receptor

effects
GI

myenteric plexus M1

increase resting tone, peristaltic activity and force of contraction of sm

increase gastric secretion

may cause cramps, nausea, vomitting, and diarrhea
Methacholine

class of drugs
pharmacological actions
dosage
clinical use
metacholine

cholinergic agonist
no nicotinic effect, given Iv
dosage: somewhat resistant to ACHE, longer duration

diagnostic tool for belladonna alkaloid poisoning

for peripheral vascular disease and paroxymal atrial tachcardia
carbochol

class of drug
pharmacological actions
dosage
clinical use
Carbacol

cholinergic agonist

actions: greater nicotinic effects than ACh
muscurinic effect on GI, urinary bladder and iris
less effective as muscurinic agonist on cardiovascular system

dosage: ophthalmic solution
resistant to ACHE

use: wide-angle glaucoma, used to produce miosis during eye surgery
side effects with local ophtalmic application of carbachol
systemic side effects-rare
pupillary constriction
accomodative spasm/headach
conjunctival hyperemia
Bethanechol
class of drug
action
dosage
clinical uses
Bethanechol
cholinergic agonist
action: similar to carbahol
no nicotinic effect
dosage: totally resistant to ACHE
given orally/subcutaneously
uses: tx: urinary retention, post-op or neurogenic types
post-op abdominal distention
antimuscurinic-rare
side effects of bethanechol
flushing/sweating
epigastric distress, abdominal cramps, salivation/diarrhea
headache/difficulty in visual accommodation
contraindications of cholinergic agonists
peptic ulcer or damaged GI wall
asthma
coronary insufficiency
caution with bradycardia/hypotension
Drug interactions for cholinergic agonist
Quinidine/procaiamide antagonize effects of bethanechol

combined with drugs that deplete serotonin (reserpine)--hypothermia
treatment for muscurine poisoning

can muscurine cross BBB
atrophine

muscurine: absorbed from GI, cross BBB
pilocarpine

class of drug
actions
dosage
use
pilocarpine

natureal alkaloid-cholinergic agonist
actions: mostly muscurinic effect some nicotinic activy
Cardiovas sys is less sensitive than other organ systems

dosage: ophthalmic solution

use: reduce pressure in glaucoma
side effects of pilocarpine
ciliary spams
conjuctival vascular congestion
headache
reduced visual acuity