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15 Cards in this Set
- Front
- Back
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Thalidomide
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used for immunosuppression (SLE, organ transplant), antiangiogenic
affects TNF-A, tox: phocomelia (flapper limbs) |
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NSAIDS
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reversibly inhibit COX 1 and 2; block PG snythesis
uses: gout, antipyetic, analgesia, antiinflammatory tox: renal damage, aplastic anemia, GI distress, ulcers |
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Strongest NSAIDs
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indomethacin (used to close PDA), ketolac
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NSAID with lowest SE profile
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naproxen
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COX 2 inhibitors
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celecoxib, valdecoxib
reversibly inhibit COX2 which only mediates pain and inflammation; does not harm gastric mucosa use: RA and OA and gout |
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Acetominophen
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reversibly inhibits COX, mostly in CNS; inactivated peripherally
antipyretic and analgesic but lacking antiinflammatory properties OD: hepatic necrosis, depletion of glutathione antidote: N-acetylcysteine- regenerates glutathione DOC OA |
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Gout drugs
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NSAIDS
colchicine probenecid allopurinol |
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colchicine
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acute gout; depolymerizes microtubules imparing leukocyte chemotaxis and degranulation
GI SE: esp if oral can also be used in prophylaxis |
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probenecid
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chronic gout; inhibits reabsorption of uric acid (also inhibits secretion of penecillin)
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allopurinol
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chronic gout; inhibits xanthine oxidase. decreases conversion of xanthine to uric acid
also used in lymphoma and leukemia to prevent tumor lysis associated urate nephropathy |
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etanercept
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recombinant TNF receptor that binds TNF-A
used for RA, psoriasis, ankylosing spondylitis |
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infliximab
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TNF-A ab; used in crohns, RA, AS, psoriatic arthritis
tox: predisposes to infections, MUST test for tb |
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cyclosporine
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binds to cyclophillins- complex blocks differentiation and activation of T cells by inhibiting calcineurin, thus preventing production of IL2
used to suppress immune system- organ transplantation, AI disorders- RA, Crohns, nephrotic syndrome predisposes to viral infections and lymphoma; nephrotoxic |
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Tacrolimus
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similar to cyclosporine; binds to FK binding protein, inhibiting secretion of IL2 and other cytokines
used in immunosuppression tox: nephrotoxic, peripheral neuropathy, HTN, pleural effusion, hyperglycemia |
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Azathiopine
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antimetabolite derivative of 6MP that interferes with metabolism and synthesis of nucleic acids - inhibits PRPP synthetase
toxic to proliferating lymphocytes use: transplantation, AI disorders (GN, hemolytic anemia) tox: bone marrow suppresion, met by xanthine oxidase |
