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15 Cards in this Set

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Thalidomide
used for immunosuppression (SLE, organ transplant), antiangiogenic
affects TNF-A, tox: phocomelia (flapper limbs)
NSAIDS
reversibly inhibit COX 1 and 2; block PG snythesis
uses: gout, antipyetic, analgesia, antiinflammatory
tox: renal damage, aplastic anemia, GI distress, ulcers
Strongest NSAIDs
indomethacin (used to close PDA), ketolac
NSAID with lowest SE profile
naproxen
COX 2 inhibitors
celecoxib, valdecoxib
reversibly inhibit COX2 which only mediates pain and inflammation; does not harm gastric mucosa
use: RA and OA and gout
Acetominophen
reversibly inhibits COX, mostly in CNS; inactivated peripherally
antipyretic and analgesic but lacking antiinflammatory properties
OD: hepatic necrosis, depletion of glutathione
antidote: N-acetylcysteine- regenerates glutathione
DOC OA
Gout drugs
NSAIDS
colchicine
probenecid
allopurinol
colchicine
acute gout; depolymerizes microtubules imparing leukocyte chemotaxis and degranulation
GI SE: esp if oral
can also be used in prophylaxis
probenecid
chronic gout; inhibits reabsorption of uric acid (also inhibits secretion of penecillin)
allopurinol
chronic gout; inhibits xanthine oxidase. decreases conversion of xanthine to uric acid
also used in lymphoma and leukemia to prevent tumor lysis associated urate nephropathy
etanercept
recombinant TNF receptor that binds TNF-A
used for RA, psoriasis, ankylosing spondylitis
infliximab
TNF-A ab; used in crohns, RA, AS, psoriatic arthritis
tox: predisposes to infections, MUST test for tb
cyclosporine
binds to cyclophillins- complex blocks differentiation and activation of T cells by inhibiting calcineurin, thus preventing production of IL2
used to suppress immune system- organ transplantation, AI disorders- RA, Crohns, nephrotic syndrome
predisposes to viral infections and lymphoma; nephrotoxic
Tacrolimus
similar to cyclosporine; binds to FK binding protein, inhibiting secretion of IL2 and other cytokines
used in immunosuppression
tox: nephrotoxic, peripheral neuropathy, HTN, pleural effusion, hyperglycemia
Azathiopine
antimetabolite derivative of 6MP that interferes with metabolism and synthesis of nucleic acids - inhibits PRPP synthetase
toxic to proliferating lymphocytes
use: transplantation, AI disorders (GN, hemolytic anemia)
tox: bone marrow suppresion, met by xanthine oxidase