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49 Cards in this Set
- Front
- Back
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1st Gen NSAIDs--examples of
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aspirin: salicylate, cheap, Naproxen (Naprosyn)
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1st Gen NSAIDs--classification(s)
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Analgesic, Antipyretic, Anti-inflammatory
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1st Gen NSAIDs--What does it do?
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Dcreases pain and deformity….inhibits platelet aggregation (clumping)
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1st Gen NSAIDs--side effects
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GI upset, GI bleeding, ototoxicity, bleeding caused by anticoagulation, BP^ due to fluid retention. Drowsiness in some.
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1st Gen NSAIDs-nursing interventions
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Assess for bruising and bleeding (abd pain, dark stools). Pt to report tinnitus.
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Safety of NSAIDs
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safest but do not prevent joint damage nor do they slow progression of connective tissue disease.
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Cox-2 inhibitors aka
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2nd Gen NSAIDs
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Cox-2 inhibitors--example(s)
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celecobix (Celebrex)---COX-2 Inhibitor
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Cox-2 inhibitors--classification(s)
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Analgesic, Antipyretic, Anti-inflammatory
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Cox-2 inhibitors--NI
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take with food or glass of water. Remain upright for 15-30 mins after taking. Do not use with aspirin, alcohol or acetaminophen
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Indole Analogues--examples
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indomethacin (Indocin)
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Indoles--classification(s)
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analgesic, anti inflammatory
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Indoles--treats
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severe ankylosing spondylitis, painful shoulders
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Indoles--SE
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Gastric bleeding, psychiatric disturbances
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Indoles--NI
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Take with food. Report signs of bleeding.
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Glucocorticoids--examples
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Cortone (cortison acetate), Deltasone (Prednisone), Delta-Cortef (Prednisolone)
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Glucocorticoids--what do they do?
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Supresses normal immune response. Suppresses inflammation,
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Glucocorticoids--SE
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muscular weakness. Osteoporosis, incr susceptibility to infections
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Glucocorticoids--NI
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give highest dose in morning. Remember that these drugs mask sign of infection so monitor for unusual drainage, oodors or elevated temp.
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Glucocorticoids--treats
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inflammatory and allergic conditions
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Glucocorticoids--can be injected where?
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into affected joint
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DMARD stands for
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Disease Modifity Anti Rhematic Drugs
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DMARD--examples of first choice
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Folex (methotrexate), Plaquenil (hydroxycloroquine sulfate), Azulfidine (sulfasalzine)---DMARDs: 1st Choice
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DMARDs--regarding safety of 1st choice drugs
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Although they can have serious side effects, they are generally the safest of the DMARDs
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DMARDs--small molecule--example
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Arava (Leflunomide)---DMARDs: small molecule
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DMARDs--small molecule--SE
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Liver toxity. Can affect fetus.
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DMARDs--small molecule--NI
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Monitor liver studies. Women should avoid conception due to teratogenic effects. Avoid alcohol.
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DMARDs--Biologic Response Modifier --example
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Humira (adalimumab)---DMARDs: BRM--also Enebrel (enteracept)
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BRM means
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biological response modifier
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Antigout--examples
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Zyloprim (Allopurinol), Benemid (probenecid)
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Antigout--Zyloprim (allopurinol)--action
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Inhibits synthesis of uric acid.
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Antigout--Zyloprim (allopurinol)--SE
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drowsiness
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Antigout--Zyloprim (allopurinol)--NI
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pt to drink 8-10 glasses of water daily to maintain output of at least 2L/day. Several weeks for full effects to show.
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Antigout--Benemid (probenecid)--action
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increases urinary excretion of uric acid.
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Antigout--Benemid (probenecid)--NI
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Do not take with penicillin.
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Antigout--Benemid (probenecid)--SE
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Urinary calculi
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BRI means
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Bone Reabsorption Inhibitors
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BRI examples
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Boniva (Ibandronate NA), Fosamax (alendronate NA), Evista (raloxifene)
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BRI--Boniva (ibandrobate NA)--treats
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osteoporosis in post menopausal women. also prevents.
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BRI--Boniva (ibandrobate NA)--NI
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Take on empty stomach upon rising. Remain upright for at least 60 minutes after taking
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BRI--Fosamax (alendronate NA)--what does it do?
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increases bone mineral density by impairing bone reabsorption
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BRI--Fosamax (alendronate NA)--SE
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GI disturbances with overdose, hypocalcemia
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BRI--Fosamax (alendronate NA)--NI
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take with 6-8 oz water upon arising. NPO for 30 mins. Remain upright for 30 mins
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BRI--Evista (raloxifene)--action
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prevents bone loss and lowers cholesterol w/o stimulating endometrium
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BRI--Evista (raloxifene)--indication
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prevents osteoporosis in postmenopausal women
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BRI--Evista (raloxifene)--SE
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flu syndrome and thrombosis
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BRI--Evista (raloxifene)--NI
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Do NOT take during pregnancy, before menopause or during periods of immobility.
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OA is treated by what categories of drugs?
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NSAIDs (salicytates are cheapest), Tylenol, indole analogs
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RA is treated by what categories of drugs?
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NSAIDs, DMARDs (1st choice, small molecule, BRM), glucocorticoids
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