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10 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Aspirin
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irreversibly inhibits COX and decreases synthesis of thromboxane and prostraglandins
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Use: (low dose) decrease aggregation. (intermediate dose) antipyretic and analgesic. (high dose) anti-inflammatory
Toxicity: gastric upset, chronic use can cause renal failure, interstitial nephritis and upper GI bleed, and Reye's syndrome in kids with viral infections |
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NSAIDs
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reversibly inhibits COX, blocks prostaglandin synthesis
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Use: anti-pyretic, analgesic, anti-inflammatory
Toxicity: renal damage, fluid retention aplastic anemia, GI distress, ulcers |
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celecoxib
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reversibly inhibits COX2 sepecifically, which is found in inflammatory cells and vascular endothelium and mediates inflammation and pain
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Use: RA and osteoarthritis, patients with gastritis or ulcers
Toxicity: increased risk of thrombosis, sulfa allergy |
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Acetaminophen
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reversibly inhibits COX, mostly in CNS, inactivated peripherally
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Use: antipyretic, analgesix, lack anti-inflammatory properties
Toxicity: overdose produces hepatic necrosis; acetaminophen metabolite depletes glutathione and forms toxi tissue adducts in liver |
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bisphosphonate (-dronate)
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inhibits osteoclastic activity and reduces bones formation and resorption of hydroxyapatite
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Use: malignancy associated hypercalcemia, Paget's, postmenopausal osteoporosis
Toxicity: corrosive esophagitis (not zoledronate), nausea, diarrhea, osteonecrosis of the jaw |
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Colchicine
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binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation,
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Use: acute Gout
Toxicity: GI side effects, especially with oral |
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Probenecid
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inhibits reabsorption of uric acid in PCT
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chronic gout
Toxicity: decreases penicillin secretion |
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Allopurinol
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inhibits xanthine oxidase, decreases conversion of xanthine to uric acid
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Use: chronic gout, lymphoma and leukemia to prevent tumor-lysis associated urate nephropathy
toxicity: increased concentrations of azathioprine and 6MP |
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Etanercept
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recombinant form of human TNF that binds TNF receptor
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Use: RA, psoriasis, ankylosising spondylitis
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infliximab
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anti-TNF antibody
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Use: Chron's, RA, ankylosing spondylitis,
Toxicity: predisposes to infections like reactivation of TB |
