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11 Cards in this Set

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Aspirin
Use- low dose decreases platelet aggregation; intermediate dose is an antipyretic and analgesic; high dose is anti-inflammatory
Toxicity- GI upset, acute renal failure with chronic use, interstitial nephritis, upper GI bleed, Reye's syndrome in children with viral infection
NSAIDs: Ibuprofen, naproxen, ketorolac, indomethacin
Use: antipyretic, analgesic, anti-inflammatory. Indomethacin to close PDA
Toxicity- Renal damage, fluid retention, aplastic anemia, GI distress, ulcers
COX-2 inhibitors (celecoxib)
Use- RA and osteoarthritis, patients with gastric ulcers or gastritis (no platelet inhibition because that is COX-1 mediated)
Toxicity- Increased risk of thrombosis, sulfa allergy, less toxic to GI mucosa than NSAIDs
Acetaminophen
Mechanism- Reversibly inhibits COX in the CNS. Inactivated peripherally
Use- Lacks anti-inflammatory properties; use instead of ASA in children
Toxicty- Hepatic necrosis with overdose; give N-acetylcysteine to regenerate glutathione
Bisphosphonates
-Dronates
Mechanism- inhibit osteoclast activity to reduce formation and resorption of hydroxyapatite
Use- Malignancy associated hypercalcemia, paget's, PM osteoporosis
Toxicity- CORROSIVE ESOPHAGITIS (except zoledronate), N/D, osteonecrosis of jaw
Colchicine
Mechanism- Binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation.
Use- Acute gout
Toxicity- GI (diarrhea)
Probenecid
Mechanism- Inhibits reabsorption of uric acid in PCT (but also inhibits secretion of penicillin)
Use- Chronic gout
Allopurinol
Mechanism- Inhibits xanthine oxidase
Use- Chronic gout, leukemia and lymphoma to prevent tumor lysis-associated urate nephropathy
Toxicity- Increases concentrations of azathioprine and 6-MP
Etanercept
Mechanism- Recombinant form of human TNF receptor that binds TNF
Use- RA, psoriasis, ankylosing spondylitis
Infliximab
Mechanism- anti-TNF antibody
Use- Crohn's, RA, ankylosing spondylitis
Toxicity- Predisposes to infection (reactivation of latent TB!!!!!)
Adalimumab
Mechanims- anti-TNF antibody
Use- Crohn's RA, psoriasis, ankylosing spondylitis