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11 Cards in this Set
- Front
- Back
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Aspirin
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Use- low dose decreases platelet aggregation; intermediate dose is an antipyretic and analgesic; high dose is anti-inflammatory
Toxicity- GI upset, acute renal failure with chronic use, interstitial nephritis, upper GI bleed, Reye's syndrome in children with viral infection |
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NSAIDs: Ibuprofen, naproxen, ketorolac, indomethacin
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Use: antipyretic, analgesic, anti-inflammatory. Indomethacin to close PDA
Toxicity- Renal damage, fluid retention, aplastic anemia, GI distress, ulcers |
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COX-2 inhibitors (celecoxib)
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Use- RA and osteoarthritis, patients with gastric ulcers or gastritis (no platelet inhibition because that is COX-1 mediated)
Toxicity- Increased risk of thrombosis, sulfa allergy, less toxic to GI mucosa than NSAIDs |
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Acetaminophen
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Mechanism- Reversibly inhibits COX in the CNS. Inactivated peripherally
Use- Lacks anti-inflammatory properties; use instead of ASA in children Toxicty- Hepatic necrosis with overdose; give N-acetylcysteine to regenerate glutathione |
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Bisphosphonates
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-Dronates
Mechanism- inhibit osteoclast activity to reduce formation and resorption of hydroxyapatite Use- Malignancy associated hypercalcemia, paget's, PM osteoporosis Toxicity- CORROSIVE ESOPHAGITIS (except zoledronate), N/D, osteonecrosis of jaw |
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Colchicine
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Mechanism- Binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation.
Use- Acute gout Toxicity- GI (diarrhea) |
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Probenecid
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Mechanism- Inhibits reabsorption of uric acid in PCT (but also inhibits secretion of penicillin)
Use- Chronic gout |
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Allopurinol
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Mechanism- Inhibits xanthine oxidase
Use- Chronic gout, leukemia and lymphoma to prevent tumor lysis-associated urate nephropathy Toxicity- Increases concentrations of azathioprine and 6-MP |
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Etanercept
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Mechanism- Recombinant form of human TNF receptor that binds TNF
Use- RA, psoriasis, ankylosing spondylitis |
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Infliximab
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Mechanism- anti-TNF antibody
Use- Crohn's, RA, ankylosing spondylitis Toxicity- Predisposes to infection (reactivation of latent TB!!!!!) |
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Adalimumab
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Mechanims- anti-TNF antibody
Use- Crohn's RA, psoriasis, ankylosing spondylitis |
