Musculoskeletal Disorders

Front 1

1.What is the basic pathobiologic target of ankylosing spondylitis?
2. T/F AS focuses on the axial skeleton
3. What genetic group is AS associated with?
4. Name some extra-articular manifestations of AS.

Back 1

1. The enthesis
2. True
3. HLA B27
4. Eyes, heart, lungs. cauda equina syndrome.

Front 2

1.What syndrome is precipitated by an infectious event? Is this syndrome HLAb27 related?

Back 2

1.Reiters Syndrome
2. Yes

Front 3

What subtype exhibits pencil in cup deformity?

Back 3

psoriatic arthritis

Front 4

The conditions last longer than 30 min, are associated with AM rituals, and improve with activity. Is this condition inflammatory or non inflammatory?

Back 4

It is inflammatory.

Front 5

Describe 3 characteristics of a non-inflammatory disorder.

Back 5

1.Short duration
2.present with advanced degenerative joint disease
3. Worsens with activity

Front 6

1.Eburnation of the bone is characteristic of what type of arthititis?
2. what is the term for calcification of the annulus fibrosus and what condition is it associated with?

Back 6

1.Osteoarthritis
2. syndesmophyte, associated with the bony bridging in spondlyoarthropathies.

Front 7

what is the formation of osteophyte at the edges of the articular surfaces associated with?
When looking at a particular joint, does OA exhibit symmetrical or asymmetrical joint involvement?
3. what process does an osteophyte represent and what is the association term for how they appear on x-ray?

Back 7

1.osteoarthritis.
2.asymmetrical
3. bone remodeling; eagles beak appeareance (lateral projection, triangular in shape)

Front 8

how do you differentiate radicular from local pain?

Back 8

local= deep and aching (soft tissue/ VB irritation)
radicular= sharp stabbing from compression of dorsal roots (projecting in dermatomal pattern)

Front 9

what condition exhibits flowin calcifications + ossifications along the anterolateral aspect of 4 contiguous vertebral bodies?

Back 9

DISH

Front 10

1.what condition exhibits fusiform, spongy swelling of the large and small joints?
2. a)what type of arthritis exhibits central erosions?b)marginal erosions?

Back 10

1.rheumatoid
2.a) OA b) rheumatoid

Front 11

1.What is the proliferative synovium responsible for bone destruction in rheumatoid?
2.T/F joint space narrowing occurs in Rhematoid
3.T/F the changes to bone and hyaline cartilage in RA occur in a symmetrical fashion in respect to an individual joint?

Back 11

1.pannus
2.true
3. true

Front 12

1.What eye condition presents with minimal pain and redness and no visual changes?
2. What arthritis is this condition associated with?

Back 12

1. episcleritis
2. rheumatoid

Front 13

What is the differential for a single swollen joint?

Back 13

septic joint (infection)
gonococcal arthritis
osteomyelitis (bone infection)
gout (crystal)
psuedogout
trauma/mechanical derangement
hemorrhage
early rheumatoid

Front 14

1.What is the key to diagnosis of monoarthritis?
2.t/f RBCs in joint fluid are pathologic

Back 14

1.joint aspiration
2.false. joints are vascular and you often get RBCs

Front 15

what crystals show as parallel yellow crystals on polarilizing microscopy?
How is its birefringence described?

Back 15

uric acid= gout (monoarticular)
strongly negativley birefringent

Front 16

How is CPPD described on miscroscopy?

Back 16

Aligned, BLUE and weakly positive birefringent.

Front 17

How are basic Ca+ phosphate crystals detected in joints?

Back 17

They aren't, they are ruled out. The crystals are not birefringent, and LM is not sensitive enough to detect. Reule out septic joint, rule out crystals we can see; CPPD.

Front 18

What does joint fluid with a very low viscosity indicate?

Back 18

an inflammatory process in the joint (normal joint fluid is viscous)

Front 19

What would you bet on if you played odds on on pt. with hx of intermittent periods of pain, esp after eating a huge steak.

Back 19

The Gout, aka crystalline disorders.