Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
What is Osteochondroma?
|
1) Most common benign bone tumor, usu. men < 25
2) Growth covered by cartilage cap 3) Originate from long bone metaphysis like around knee 4) RARELY transform to chondrosarcoma |
|
|
What is Giant Cell Tumor?
|
1) M=F ages 20-40 yrs
2) Common benign 3) Spindle cells mixed with giant cells 4) > 50% in knee area 5) "Soap bubble" on x-ray |
|
|
What is Osteosarcoma?
|
Most common primary bone malignant bone tumor, affecting young men 10-20 yrs usually around knee
|
|
|
What are the si/sx of Osteosarcoma?
|
1) Pain, fracture, swelling
2) High ALP 3) Codman's Triangle: elevated periosteum by expanding tumor |
|
|
What predisposes someone to Osteosarcoma?
|
1) Radiation
2) Retinoblastoma (del 13q) 3) Bone infarct |
|
|
What is Chondrosarcoma?
|
Malignant cartilage tumor, in men 30-60 yrs
|
|
|
What is Ewing's Sarcoma?
|
Small anaplastic blue cell tumor resembling malignant lymphoma, see "ONION SKINNING" on x-ray
|
|
|
Who gets Ewing's Sarcoma?
|
1) Young boys < 15 yrs
2) 11:22 translocation |
|
|
What is Multiple Myeloma?
|
Malignant clonal neoplasm of Plasma Cells producing:
- whole Abs (IgM, IgG, etc.) - light chain Abs - or no Abs (just inc. B-cells) |
|
|
Who gets Multiple Myeloma?
|
Patients > 40 yrs, black twice as likely as white
|
|
|
How does Multiple Myeloma present?
|
1) Bone pain, worse with movement, back and ribs
2) Punched-out lytic bone lesions 3) Hypercalcemia |
|
|
How do you Dx Multiple Myeloma?
|
1) SPEP: M-spike if clones making whole Abs
2) UPEP: spike if clones make light chains only 3) Osteolytic bone lesions 4) Bence-Jones proteinuria |
|
|
What are Bence-Jones proteins?
|
Ab light chains in urine
|
