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81 Cards in this Set
- Front
- Back
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hemidesmosomes/___________
desmoplakin/___________ E-cadherin/____________ |
integrin
keratin actin |
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E-cadherin is for zona __________
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adherens
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what is the dihydropyridine receptor?
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vg Ca channel in T tubule
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what bands shrink in sarcomere?
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HIZ
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what does myosin light chain phosphatase do? kinase?
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phosphatase relaxes (phloppy)
kinase kontracts |
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achondroplasia affects ___________ ossification
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endochondral
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subchondral bone formation and sclerosis are features of...?
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OA
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what are the systemic symptoms of RA?
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pleuritis, pericarditis, fever, fatigue
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which HLA for RA?
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HLA-DR4
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which joint is Boutonniere's deformity?
which joint is swan-neck? |
PIP
DIP |
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what's Felty's syndrome?
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RA
splenomegaly neutropenia |
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what causes quadroplegia in RA?
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involvement of the cervical spine
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RA is associated with what conditions?
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Sjogren's syndrome
sarcoidosis |
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most common form of arthritis in sexually active adults?
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gonococcal spetic arthritis
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what are "joint mice"?
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small peices of cartilage broken off in joint. produce non-inflammaotory arthritis
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what is osteopetrosis?
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abnormal osteoclasts-->increased bone density
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what is osteomalacia?
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defective mineralization of osteoid
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high alk phos?
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Paget's
osteitis fibrosa cystica |
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low calcium in osteomalacia results in _____ PTH and ________ phosphate
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increased PTH
decreased phosphate |
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calcium, phosphate, and alkphos are all normal?
calcium, phosphorus, PTH normal? |
osteopetrosis
Paget's |
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hyperparathyroid causes...
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osteitis fibrosa cystica
high calcium low phosphorus HIGH ALKPHOS |
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chronic renal failure causes...
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osteitis fibrosa cystica
osteomalacia/rickets |
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mosaic lamellar bone pattern?
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Paget's
due to both osteoclastic and osteoblastic activity |
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alkphos is normal in?
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osteopetrosis
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Albright's syndrome is a form of ____________
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polyostotic fibrous dysplasia
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unmineralized whorls of connective tissue?
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polyostotic fibrous dysplasia
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unilateral bone lesions, "Coast of Main" cafe au lait spots, precocious puberty?
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Albright's syndrome
(a form of polyostotic fibrous dysplasia) |
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what is polymyalgia rheumatica?
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pain and stiffness in the shoulders and hips
associated with temporal (giant cell) arteritis |
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AV shunts in bone-->high output cardiac failure?
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Paget's
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proximal muscle weakness caused by CD8 cells attacking myofibers?
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polymyositis/dermatomyositis
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associated with an increased risk of malignancy?
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dermatomyositis
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increased CK and aldolase, positive ANA and anti-Jo?
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polymyositis/dermatomyositis
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esophageal dysmotility?
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scleroderma
mixed connective tissue disease |
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antibodies to U1 RNP?
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mixed connective tissue disease
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"ragged red fibers"?
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mitochondrial myopathy
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what is mixed connective tissue disease?
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Raynaud's
arthralgia, myalgias, fatigue esophageal hypomotility |
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elevated ESR, treat with prednisone?
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polymyalgia rheumatica
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increased risk of B cell lymphoma?
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Sjogren's syndrome
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affects women between 40 and 60?
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Sjogren's syndrome
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what else in sicca syndrome besides dryness?
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chronic bronchitis
reflux esophagitis |
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what causes false positives on VDRL for lupus?
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anti-phospholipid antibodies
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which antibody in lupus is specific and indicates poor prognosis?
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anti-dsDNA
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oropharyngeal ulcers, neurologic disorders, pleuritis, pericarditis?
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SLE
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celiac sprue tends to affect what part of the GI tract?
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jejunum
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what is dermatitis herpetiformis?
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pruritic papules and vesicles associated with Celiac
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celiac can lead to what malignancy?
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T cell lymphoma
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Goodpastures causes a _________ GN
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cresecentic
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Goodpastures is a Type ______ hypersensitivity
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Type II
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Schaumann and asteroid bodies?
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sarcoidosis
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uveoparotitis occurs in ________
uveitis occurs in _________ parotid enlargement in ________ |
sarcoidosis
ankylosing spondylitis, Reiter's syndrome Sjogren's syndrome |
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Bells palsy, hypercalcemia?
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sarcoidosis
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bilateral hilar lymphadenopathy?
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sarcoidosis
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anergy despite gammaglobulinemia?
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sarcoidosis
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apical lung fibrosis?
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ankylosing spondylitis
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cauda equina syndrome?
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ankylosing spondylitis
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sausage digits (dactylitis)?
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Reiter's syndrome
psoriatic arthritis |
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"pencil in cup"?
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psoriatic arthritis
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Reiter's syndrome follows..
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GI or chlamydia infections
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what does CREST stand for?
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calcinosis
Raynaud's esophageal dysmotility slcerodactly telangiectasia |
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anti-centromere antibody?
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CREST
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Scl-70 antibody?
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diffuse scleroderma
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pathology in scleroderma?
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fibrosis and collagen deposition
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superficial nodular phlebitis is associated with..
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Buerger's disease
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elevated ESR?
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Takayasu arteritis
polymyalgia rheumatica temporal arteritis (marked elevation) |
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skin nodules and ocular disturbances?
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Takayasu artertitis
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aortic arch and great vessels
granulomatous? |
Takayasu arteritis
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thrombosing vasculitis?
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Buerger's disease
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branches of the carotid
granulomatous? |
temporal (giant cell) arteritis
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jaw claudication?
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temporal arteritis
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P or C ANCA?
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microscopic polyangiitis
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what is polyartertitis nodosa?
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necrotizing
medium sized vessels of kidney and viscera |
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Hep B seropositivity?
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polyarteritis nodosa
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triad of Wegener's?
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focal nectrotizing vasculitis
necrotizing granulomas of lung and upper airway necrotizing glomerulonephritis |
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cyclophosphamide and steroids are for...
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Wegener's and polyarteritis nodosa
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what is microscopic polyangiitis?
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like Wegner's but lacks granulomas
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P or C-ANCA positive?
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microscopic polyangiitis
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what are the ANCA positive vasculitides?
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microcsopic polyangiitis
primary pauci-immune crescentic glomerulonephritis Churg-Strauss syndrome |
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coronary aneurysms?
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Kawasaki disease
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what is Kawasaki disease?
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acute necrotizing vasculitis of kids.
self limiting |
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most common childhood systemic vasculitis?
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Henoch-Schoenlein purpura
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the granulomatous vasculitides?
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Takayasu
Temporal Churg-Strauss |
