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81 Cards in this Set

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  • Back
hemidesmosomes/___________
desmoplakin/___________
E-cadherin/____________
integrin
keratin
actin
E-cadherin is for zona __________
adherens
what is the dihydropyridine receptor?
vg Ca channel in T tubule
what bands shrink in sarcomere?
HIZ
what does myosin light chain phosphatase do? kinase?
phosphatase relaxes (phloppy)
kinase kontracts
achondroplasia affects ___________ ossification
endochondral
subchondral bone formation and sclerosis are features of...?
OA
what are the systemic symptoms of RA?
pleuritis, pericarditis, fever, fatigue
which HLA for RA?
HLA-DR4
which joint is Boutonniere's deformity?
which joint is swan-neck?
PIP
DIP
what's Felty's syndrome?
RA
splenomegaly
neutropenia
what causes quadroplegia in RA?
involvement of the cervical spine
RA is associated with what conditions?
Sjogren's syndrome
sarcoidosis
most common form of arthritis in sexually active adults?
gonococcal spetic arthritis
what are "joint mice"?
small peices of cartilage broken off in joint. produce non-inflammaotory arthritis
what is osteopetrosis?
abnormal osteoclasts-->increased bone density
what is osteomalacia?
defective mineralization of osteoid
high alk phos?
Paget's
osteitis fibrosa cystica
low calcium in osteomalacia results in _____ PTH and ________ phosphate
increased PTH
decreased phosphate
calcium, phosphate, and alkphos are all normal?
calcium, phosphorus, PTH normal?
osteopetrosis
Paget's
hyperparathyroid causes...
osteitis fibrosa cystica
high calcium
low phosphorus
HIGH ALKPHOS
chronic renal failure causes...
osteitis fibrosa cystica
osteomalacia/rickets
mosaic lamellar bone pattern?
Paget's
due to both osteoclastic and osteoblastic activity
alkphos is normal in?
osteopetrosis
Albright's syndrome is a form of ____________
polyostotic fibrous dysplasia
unmineralized whorls of connective tissue?
polyostotic fibrous dysplasia
unilateral bone lesions, "Coast of Main" cafe au lait spots, precocious puberty?
Albright's syndrome
(a form of polyostotic fibrous dysplasia)
what is polymyalgia rheumatica?
pain and stiffness in the shoulders and hips
associated with temporal (giant cell) arteritis
AV shunts in bone-->high output cardiac failure?
Paget's
proximal muscle weakness caused by CD8 cells attacking myofibers?
polymyositis/dermatomyositis
associated with an increased risk of malignancy?
dermatomyositis
increased CK and aldolase, positive ANA and anti-Jo?
polymyositis/dermatomyositis
esophageal dysmotility?
scleroderma
mixed connective tissue disease
antibodies to U1 RNP?
mixed connective tissue disease
"ragged red fibers"?
mitochondrial myopathy
what is mixed connective tissue disease?
Raynaud's
arthralgia, myalgias, fatigue
esophageal hypomotility
elevated ESR, treat with prednisone?
polymyalgia rheumatica
increased risk of B cell lymphoma?
Sjogren's syndrome
affects women between 40 and 60?
Sjogren's syndrome
what else in sicca syndrome besides dryness?
chronic bronchitis
reflux esophagitis
what causes false positives on VDRL for lupus?
anti-phospholipid antibodies
which antibody in lupus is specific and indicates poor prognosis?
anti-dsDNA
oropharyngeal ulcers, neurologic disorders, pleuritis, pericarditis?
SLE
celiac sprue tends to affect what part of the GI tract?
jejunum
what is dermatitis herpetiformis?
pruritic papules and vesicles associated with Celiac
celiac can lead to what malignancy?
T cell lymphoma
Goodpastures causes a _________ GN
cresecentic
Goodpastures is a Type ______ hypersensitivity
Type II
Schaumann and asteroid bodies?
sarcoidosis
uveoparotitis occurs in ________
uveitis occurs in _________
parotid enlargement in ________
sarcoidosis
ankylosing spondylitis, Reiter's syndrome
Sjogren's syndrome
Bells palsy, hypercalcemia?
sarcoidosis
bilateral hilar lymphadenopathy?
sarcoidosis
anergy despite gammaglobulinemia?
sarcoidosis
apical lung fibrosis?
ankylosing spondylitis
cauda equina syndrome?
ankylosing spondylitis
sausage digits (dactylitis)?
Reiter's syndrome
psoriatic arthritis
"pencil in cup"?
psoriatic arthritis
Reiter's syndrome follows..
GI or chlamydia infections
what does CREST stand for?
calcinosis
Raynaud's
esophageal dysmotility
slcerodactly
telangiectasia
anti-centromere antibody?
CREST
Scl-70 antibody?
diffuse scleroderma
pathology in scleroderma?
fibrosis and collagen deposition
superficial nodular phlebitis is associated with..
Buerger's disease
elevated ESR?
Takayasu arteritis
polymyalgia rheumatica
temporal arteritis (marked elevation)
skin nodules and ocular disturbances?
Takayasu artertitis
aortic arch and great vessels
granulomatous?
Takayasu arteritis
thrombosing vasculitis?
Buerger's disease
branches of the carotid
granulomatous?
temporal (giant cell) arteritis
jaw claudication?
temporal arteritis
P or C ANCA?
microscopic polyangiitis
what is polyartertitis nodosa?
necrotizing
medium sized vessels of kidney and viscera
Hep B seropositivity?
polyarteritis nodosa
triad of Wegener's?
focal nectrotizing vasculitis
necrotizing granulomas of lung and upper airway
necrotizing glomerulonephritis
cyclophosphamide and steroids are for...
Wegener's and polyarteritis nodosa
what is microscopic polyangiitis?
like Wegner's but lacks granulomas
P or C-ANCA positive?
microscopic polyangiitis
what are the ANCA positive vasculitides?
microcsopic polyangiitis
primary pauci-immune crescentic glomerulonephritis
Churg-Strauss syndrome
coronary aneurysms?
Kawasaki disease
what is Kawasaki disease?
acute necrotizing vasculitis of kids.
self limiting
most common childhood systemic vasculitis?
Henoch-Schoenlein purpura
the granulomatous vasculitides?
Takayasu
Temporal
Churg-Strauss