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25 Cards in this Set
- Front
- Back
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Idiopathic Inflammatory Myopathy: location of muscle weakness
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- Symmetric
- Proximal |
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Idiopathic Inflammatory Myopathy: reflexes
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Normal
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Idiopathic Inflammatory Myopathy: serum findings
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Inc: Muscle enzymes (CK, Adolase, AST/ALT, LDH, Myoglobin)
Pos: ANA, anti-Jo-1 |
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Idiopathic Inflammatory Myopathy: treatment
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steroids
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Idiopathic Inflammatory Myopathy: Drug that's always in differential
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Statins
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Idiopathic Inflammatory Myopathy: Type of infiltrate in
- DM - PM |
- DM: perivascular, predominantly B-cells and CD4+ cells, capillaries stain for complement components
- PM: CD8+, invade muscle fibers |
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Lofgren's syndrome
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Acute Sarcoidosis - Triad:
1. Bilateral hilar adenopathy 2. Ankle periarthritis 3. Erythema nodosum |
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Ankylosing Spondylitis
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Chronic inflammatory disease of spine and sacroiliac joints
- ankylosis (stiff spine b/c fusion of joints) - uveitis - aortic regurgitation |
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Antisynthetase syndrome
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- Idiopathic Lung Disease
- myositis - arthritis - Raynauds DR3 DRW52 |
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PSS: Autoantibodies
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- Anti-topoisomerase I --> aggressive, more likely end organ disease
- Anti-centromere --> less aggressive, CREST |
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PSS: CREST
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C: Calcinosis
R: Raynaud's E: Esophageal dysmotility S: Sclerodactyly T: Telangectasia |
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Juvenile rheumatoid arthritis
- Still's - Polyarticular - Pauciarticular |
RA-
- Still's - fever, rash, polyarthritis, lymphadenopathy, neutrophilic leukocytosis - Pauciarticular - limited to a few joints, uveitis & potential blindness, ANA+/- |
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Parvovirus (B17)
- Pathogenesis - Clinical |
Fifth's Disease
IgM --> immune complexes --> - Children: Fever, then RASH - Adults: Fever, then ARTHRITIS Infects erythroblasts --> lysis --> anemia RBC destruction in fetus --> anemia, CHF, edema: hydrops fetalis |
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Polymyalgia rheumatica
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Associated with temporal arteritis
Over 50 yrs old - pain and stiffness in shoulders and hips - fever - weight loss - malaise - no muscle weakness inc esr normal ck treatment - prednisone |
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Paget's Disease
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- Osteoclastic phase, followed by osteoblastic phase (inc alk phos)
- Thick, weak bone (mosaic bone) - Head involvement --> headaches, inc hat size - Treat: Bisphosphonates, calcitonin |
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Focal or systemic:
- Paget's - HPT - Osteoporosis |
- Pagets - focal
- HPT - systemic - Osteoporosis - systemic |
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6 causes of gout
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1. alcoholism
2. Thiazide diuretics 3. leech-nyhan 4. high cell turnover 5. von gierke's 6. prpp excess |
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Antiphospholipid antibodies
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Anticardolipin antibody and lupus anticoagulant
Lupus anticoagulant Anti-b2 glycoprotein 1 |
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Antiphospholipid syndrome - associated with:
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1. Sle
2. RA, sjogren, hiv |
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Anti-pl sybdrome: lab findings
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- false positive syphilis test
- high ptt (lupus abticoagulant) - anticardolipin antibodies - anti b2 glycoprotein 1 antibodies |
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Clinical findings in APLS
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Spontaneous abortions - thrombosis of parental blood vessels
Strokes Dvt Hepatic vein thrombosis Livedo retucularis |
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Complications of pagets
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- fractures
- osteogenic sarcoma - high output heart failure. ( av connections in vascular bone) |
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Which alk phosphate is which?
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Liver lives, bone burns
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Sarcoidosis: GRAIN
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- Gammaglobulins
- Rheumatoid Arthritis - ACE increase - Interstitial fibrosis - Noncaseating fibroma |
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Dermatitis herpetiformis: histology
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IgA deposits
PMN, fibrin - microabscesses |
