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8 Cards in this Set
- Front
- Back
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Benzodiazepines
Diazepam (Valium) |
Bind to sep. allosteric site increase binding of GABA to A-Rec sit leading to more frequent opening of Cl channel
Centrally acting Antispastic effect in pt w/SCI, reduxn in mm tone in pt w/central lesions req large, sedating dose Anti-anxiety AE-sedation |
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Baclofen
Lioresal |
Centrally acting
Gaba-B agonist-decrease AC act-decrease Ca-dec glutamate release (SAME site) Spasticity in MS, clonus, muscular rigidity SCI, other SC disease NOT for rheumatic disorder spasms PO, longterm intrathecal infusion, excreted via kidneys CONTRA stroke, preg Hallucinations+seizures w/abrupt withdraw oral admin |
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Tizanidine
Zanaflex |
Centrally acting
alpha-2 agonist, imidazoline agonist, inhibits release of glutamate MS, SCI PO |
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Dantrolene
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ONLY peripherally-acting
Interferes w/release of Ca from SR via ryanodine-R channel binding skeletal mm only Malignant hyperthermia AE-general mm weakness, sedation, chemical hepatitis |
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Gabapentin
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Non selective, indirectly acting GABA agonist
Anti-spastic, anti-convulsive Bipolar adjunct Rx |
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Botulinum toxin
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Prevents release of Ach from vesicles, injxn into striated mm, neuromm jxn
Local injxn |
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Cyclobenzaprine
Flexaril |
Antispastic
Decreases excitatory drive of descending serotonergic neurons to MNs in ventral horn Local musculoskeletal pain associated w/spasms not due to SCI, CP Avoid w/glaucoma, elderly, anti-muscarinic EFX Confusion, hallucinations, increased QT, torsades |
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Riluzole
Rilutek |
Inhibits glutamate release and inactivation of voltage depend Na channels
ALS |
