Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
common shape of denervated muscle fibers?
|
small and angular fibers, with loss of myofilaments
|
|
|
fast twich vs. slow twich?
|
type II and type I respectively
|
|
|
normal fiber-type grouping looks like what?
|
checker board
|
|
|
reinnervation causes what kind of appearence in stains?
|
target fiber/cells
|
|
|
pale fibers indicate?
|
necrosis
|
|
|
location of dystrophin, sarcoglycans?
|
dystrophin just inside sarcolemma,
sarcoglycan embedded in sarcolemma |
|
|
reason for huge cells in early stage of myonecrosis?
|
compensation of remaining healthy fibers in cells
|
|
|
sarcoglycan depletion result in what disease?
|
limb girdle diseae
|
|
|
genetic defect difference between becker and duchenne?
|
becker has in-frame mutation, duchenne has out-frame causing a shift mutation
|
|
|
which myopathy is x-linked? recessive?
|
x-linked: duchenne
recessive: limb-girdle |
|
|
stain used to detect macrophages?
|
esterase stain
|
|
|
biopsy of myotonic disorders have atrophy of which fibers?
|
type I fibers
|
|
|
genetic anticipation?
|
increase length of trinucleotide repeats that result in earlier onset of sx.
|
|
|
histo characteristic of myotonic dystorphies?
|
centrally located nuclei in otherwise normal looking tissue
|
|
|
calpain 3 mutation causes?
|
severe childhood autosomal reccesive muscular dystrophy
|
|
|
pachygyria caused by?
|
dystroglycan defect
|
|
|
handshake dx.?
|
myotonic dystrophy, pt. cannot let go
|
|
|
internal nuclei in muscle cells found in which muscle disease?
|
myotonic dystrophy
|
|
|
difference between congenital myopathy vs. muscular dystrophy?
|
myopathy involves the contractin fibers, dystrophies involve the membrane
|
