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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What blocks cholinoreceptors that are activated by muscarine?
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atropine
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What are the actions of the Beta-2 receptors?
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accelerate the heart, increase contraction of the heart, relax bronchiolar smooth m., bladder and uterus, gluconeogenesis and glycogenolysis
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What are the actions of the alpha receptors?
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contract blood vessels, uterus,skin and smooth m., ejaculation of penis, increase apocrine and eccrine sweat glands and cause gluconeogenesis and glycogenolysis
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What is the action of M2?
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decrease heart rate and contractility, suppresses AV conduction
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M2 is a muscarinic receptor (mAchR)
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What is the job of the beta and gamma subunits of the G protein?
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Beta and Gamma subunits transmit the signal for hyperpolarization on the potassium channel.
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M2 receptors
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What defines the receptor subtype?
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the antagonist that blocks it.
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ex: nicotinic and muscarinic receptors
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Which receptors contract and relax the eye?
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Alpha-1 receptor contracts the radial muscle and the Beta receptor relaxes the circular muscle (SS). M3 contracts both the radial and circular muscle (PS)
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SS and PS
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What is atropine's action on pelvic visceral smooth m. organs (bladder, uterus and penis)?
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It blocks the action of muscarinic agonists administered (SS), but is ineffective in blocking PS responses.
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Which muscarinic receptors control the parietal and chief cells of the stomach?
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M1
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What is the action of the odd numbered muscarinic receptors (mAchR)- M1, M3, M5?
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They couple through Gq-G proteins to increase cytosolic calcium levels and are stimulatory to cellular activity.
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What is the effect of stimulating vascular mAchR's?
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It causes a fall in peripheral resistance which causes decr. BP and reflex tachycardia.
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What is the action of pilocarpine?
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muscarinic agonist used for acute and chronic glaucoma; topical for miotic action on the eye
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