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8 Cards in this Set
- Front
- Back
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Drugs That Lower LDL Cholesterol Levels
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HMG-CoA reductase inhibitors (Statins)
Bile acid–binding resins Nicotinic acid Fibric acid derivatives (fibrates) |
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HMG-CoA reductase inhibitors (Statins)
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Prototype = Lovastatin [Mevacor]
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Lovastatin:
*Increases number of LDL receptors Inhibits liver enzyme involved in cholesterol synthesis |
Lovastatin beneficial actions = *Lowers LDL
also raises HDL also increases plaque stability |
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Lovastatin Adverse effects
*Headache Rash Hepatotoxicity (rare) *Category X |
Nicotinic Acid (Niacin)
Decreases production of VLDLs and LDLs Inhibition of *lipolysis in adipose tissue |
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Nicotinic Acid SE:
*Skin (Flushing) Gastrointestinal *Hepatotoxicity Hyperglycemia |
Bile Acid–Binding Resins
Cholestyramine [Questran] Increases LDL receptors in liver |
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Cholestyramine:
Prevents reabsorption of bile in intestine & Accelerates bile excretion |
Cholestyramine SE:
(Not absorbed from GI) *Constipation *Decreased absorption of fat-soluble vitamins (A, D, E, & K) |
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Fibric Acid (Fribrates)
Gemfibrozil [Lopid] |
Gemfibrozil
Mechanism through activation of PPAR-gamma (?), which increases clearance of VLDLs |
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Gemfibrozil
Reduces high triglyceride levels |
Gemfibrozil SE:
Rashes Gastrointestinal Gallstones Hepatotoxicity |
