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10 Cards in this Set
- Front
- Back
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Antidysrhythmic Drugs
Fall '09 |
Dysrhythmias:
Abnormality in rhythm of the heartbeat 2 Types of dysrhythmias: Tachydysrhythmias Bradydysrhythmias |
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Based on effects on ion movement (“Vaughan Williams classification”)
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Each class is prescribed a different drug (refer to picture on lecture slide):
Class I sodium channels blockers Class II beta blockers Class III K+ channel blockers Class IV Ca+ channel blockers Other digoxin, adenosine, Mg |
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Note cards on these drugs will only include highlighted, need to know information.
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All other information on the drug, refer to your lecture slides.
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Class 1A Agents QUINIDINE
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Class 1A Agents QUINIDINE
Used supraventricular (atrial flutter or a-fib) and ventricular dysrhythmias (v-tach) Blocks sodium channels SE: Cardiotoxicity DDIs: digoxin and warfarin |
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Class 1B Agents LIDOCAINE [Xylocaine]
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Class 1B Agents LIDOCAINE [Xylocaine]
Short term ventricular dysrhythmias Used supraventricular (atrial flutter or a-fib) and ventricular dysrhythmias (v-tach) Blocks sodium channels (Accelerate repolarization with little or no effect on ECG) SE: paresthesias |
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Class II Beta Blockers PROPRANOLOL [Inderal]
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Class II Beta Blockers PROPRANOLOL [Inderal]
Nonselective beta adrenergic antagonist Use: if excessive sympathetic stimulation tachydysrhythmias, esp |
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Adverse Effects
Propranolol |
Adverse Effects Propranolol:
By blocking cardiac beta1 receptors Can cause heart failure, AV block, sinus arrest, hypotension By blocking beta2 receptors Can cause bronchospasm in patients with asthma |
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Class III Potassium Channel Blockers (Bretylium)
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Class III Potassium Channel Blockers (Bretylium):
Short term therapy w/severe ventricular dysrhythmias Delay repolarization of fast potentials SE: Profound hypotension (66% of pts) |
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Class IV Calcium Channel Blockers
Verapamil [Calan] and dilitiazem [carizem] only CCBs active in heart |
Class IV Calcium Channel Blockers
Delays AV nodal conduction Reduces myocardial contractility |
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Class IV Calcium Channel Blockers
Adverse Effects & DDI's |
Class IV Calcium Channel Blockers
SE: hypotension and edema DDIs: Elevated digoxin levels and increased risks for effects if combined with beta blockers |
