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6 Cards in this Set
- Front
- Back
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Epidemiology: who's affected? (3)
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Temperate climate (England, scotland - rare black)
Age: 30's Women |
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Common symptoms [at presentation] (7)
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NB: AT PRESENTATION THIS CONDITION IS USUALLY MONOSYMPTOMATIC
Memory Aid: U LANDED Unilateral optic neuritis (i.e. pain movement eye and decreases central vision) Leg weakness Ataxia (Cerebellar symptom) Numbness or tingling limb Diploplia (Cerebellar symptom) Erectile dysfunction Dysphagia |
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Clinical features (4)
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Dysaesthesia (unpleasant sensation)
Hemianopia Fatigue (altered cognition, memory) Hyperreflexia |
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Test cerebellar function? (6)
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Learning aid: DANISH
Dysdiadochokinesis Ataxia (gait) Nystagmus Intentional tremor Slurred speech Hypotonia |
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Tests? (5)
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CSF (LP) shows oligoclonal bands IgG, [high lymphocytes + low protein]
Visual evoked potential MRI (sensitive but not specific for plaques) Myelin oligodendrocyte glycoprotein (MOG) antibodies Myelin basic protein (MBP) |
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Rx MS: 2 x 1st + 2 x 2nd line medications
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Methylprednisolone
Interferon (decreases relapse rates)INF-1B INF1-A 2nd liners: Alemtuzumab Mitoxantrone |
