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17 Cards in this Set
- Front
- Back
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MS Etiology?
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-immunologic mechanism
-latent virus (herpes) -genetics |
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MS Prevalence?
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-between 20-50 y/o
-women:men = 2:1 -more common in temperate climate -more common w/ Northern European ancestry |
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MS Course?
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-depends on person and subtype
**PERIODS OF EXACERBATIONS & REMISSIONS MOST COMMON |
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MS Pathophyiolgoy?
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1)Immune response = T-lymphocytes, macrophages, and antibodies
2)T-lymphocytes dystroy myelin & decrease nerve conduction 3)Inflammations surround lesion 4)Oligodendrocytes cannot repair myelin 5)Gliosis = plaques |
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What is the clinical criteria for MS?
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History of exacerbations & remissions AND positive results from either or both:
-MRI -CSF analysis (elevated IgG levels) |
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MS Clinical Features?
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-weakness
-visual & oculomotor abnormalities -paresthesias -spasticity & tremors -urinary dysfunction |
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4 MS SUBTYPES
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1)Progressive-Relapsing
2)Primary-Progressive 3)Secondary-Progressive 4)Relapsing-Remitting |
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Progressive-Relapsing
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-clear exacerbations
-occur from onset -5% |
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Primary-Progressive
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-slow but continuous decline in neuro function
**NO RELAPSE/REMISSION -SEVER disability develops early -10% |
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Secondary-Progressive
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**Begins as relapsing-remitting
-then neuro function decline -50% |
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Relapsing-Remitting
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-clearly defined exacerbations or relapses w/ acute decline in neuro func
**MOST COMMON 85% |
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Co-morbidities
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-Osteoporosis
-Diabetes |
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Lifestyle Factors
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-Stress
-Viral or bacterial infection -Smoking -Extreme body heat |
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Enironmental Factor
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Temperate Climate
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Prevention Factors
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STOP SMOKING
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Typical Medical Treatment
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-Corticosteriods for acute exacerbations
-Immunornodulatros to PREVENT exacerbations -Baclofen for spasticity Gabapentin or tricyclic antidepressants for PAIN -Regular exercise |
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Non-traditional Medical Treatment
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VITAMIN D
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