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11 Cards in this Set
- Front
- Back
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inductive sites of the GALT are
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peyer's patches and isolated lymphoid follicles (ILF's)
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effector sites are found where in GALT
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under lamina propria/ epithelial cells
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follicle associated epi in GALT covers what? Describe it.
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cover's ILF's and Peyer's patches. Its flat with no glycocalyx. Their is a subepithelial dome that contains lots of dendritic cells. M cells are specialized epithelial cells, and they function by grabbing antigens in the gut and bringing them through to be presented to lymph tissue.
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What often crosses gut epi to the lumen to serve as a first line of defense against pathogens and as a maintenance mechanism of gut-flora homeostasis?
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IgA
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What cells in the sub epithelial dome maybe one of the mechanisms that prevent an all out immune response? (hint it is an antigen presenter...)
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immature/myeloid dendritic cell's that are CD11b+ and CD8a-.
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For IgA transport to the lumen, IgA in this form must bind transporters on the basolateral membrane.
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dimeric IgA which is then cleaved before entering lumen
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what are the two effector sites in the MALT?
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one in lamina propria and one in intraepithelial site (note intraepi site only contains T cells)
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In MALT CD4 TH1 cells secrete what cytokines?
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IL2, IFNy, TNF-B
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In MALT CD4 TH2 cells secrete what cytokines?
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IL4, IL5, IL6, IL13
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In MALT CD4 Treg cells secrete what cytokines?
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TGF-B and IL-10
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B cells in MALT secrete what?
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IgG1 and IgA
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