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34 Cards in this Set
- Front
- Back
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a disease marked by the proliferation of lymphocytes within the nodes and spleen rather than the marrow |
very similar to CLL to the point where some say they're the same thing basically |
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NHL is often widespread at presentation affecting |
any organ with lymphatic tissue in it |
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What is the classic presentation of NHL? |
painless lymphadenopathy |
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are the nodes red, warm or tender? |
no |
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What are "B" symptoms? |
fever, weight loss, drenching night sweats etc. |
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the best initial test for lymphoma would be... |
excisional biopsy of the node
CBC is uusally NORMAL |
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How do we use LDH in NHL? |
it can help us tell severity |
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How do we then go about treating NHL? |
it depends on staging first |
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how do we stage NHL? |
Ct chest, abdomen and pelvis
+
bone marrow biopsy |
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Why do we not do a needle aspiration of the node ? |
because simply gathering the cells is not enough for dx. They just look norml |
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stage 1 lymphoma is defined by |
1 lymph node group is involved |
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stage 2 |
two or more are involved but they're on the same side of the diaphragm |
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stage 3 |
both sides of the diaphragm |
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stage 4 |
widespread disease |
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mgmt for local lymphoma disease |
local radiation and small dose/course of chemo |
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classic treatment for advanced disease |
R CHOP |
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what is R CHOP? |
rituximab
cyclophosphamide adriamycin or doxorubicin O= vincristine P= prednisone |
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if you a GALT lymphoma then what do you do? |
eradicate the H pylori with clarithromycin and amoxicillin |
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What is the only thing that really separates HL from NHL? |
presence of Reed Sternberg cells on periphery |
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One prognostic difference between NHL and HL? |
HL is usually early stage at presentation |
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What part of the body is most affected by HL? |
the neck |
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What are the two subtypes for HL and how do they link to px? |
lymphocyte predominant and lymphocyte depleted (has a much worse px) |
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what subtype of NHL has the worst prognosis? |
Burkitt lymphoma |
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treatment for stage 1 and 2 HL? |
local radiation and small course of chemo |
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for Stage III and IV HL? |
ABVD
adriamycin bleomycin vinblastine dacarbazine |
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Who else gets ABVD even at early stage? |
anyone that has B symptoms |
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What type of risk does radiation carry? |
it raises risks of all sorts of solid tumors in the breast, thyroid, and lung |
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so patients should undergo |
screening for breast cancer as long as 8 years following treatment |
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what is the risk to the heart? |
increases risk of early CAD |
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what test is used to assess cardiac function before using adriamycin or doxorubicin? |
MUGA
it's a nuclear ventriculogram used to assess LV function |
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side effect of vincristine |
peripheral neuropathy
it messes with axonal transport |
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side effect of bleomycin |
lung fibrosis |
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cyclophosphamide |
hemorrhagic cystitis |
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cisplatin |
renal and ototoxicity |
