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12 Cards in this Set
- Front
- Back
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What two things is likely to initiate the rheumatoid process?
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Immunogenetically susceptible host and some unknown antigen
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What is activated by the unknown antigen of RA?
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CD4+ T cells.
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The transudation of fluid and transmigration of lymphocytes to the synovium and PMNs to the synovial fluid causes what to happen?
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relative synovial hypoxia leads to transcription of VEGF and VEGFR which leads to angiogenesis, which allows the scaffold upon which synovitis can grow.
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What are three main immune mediated processes that occur in RA?
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1. B cell activation
2. Macrophage activation 3. Endothelial activation |
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What is a possible result of B cell activation in RA?
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Formation of Rheumatoid factor and subsequent joint injury.
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Activation of macrophages produces which cytokines?
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IL 1, IL 6 and TNF Alpha
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What is the effect of cytokines released by macrophage activation?
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Stimulates proliferation and secretion of collagenase, stromelysin, elastase, PGE2 and other enzymes by Fibroblasts, chondrocytes and synovial cells.
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What are the results of endothelial activation by T cells in RA?
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Express adhesion molecules (ICAM1 and VCAM1) which causes the accumulation of inflammatory cells around the joint.
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What is the pannus composed of?
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Inflammatory tissue that invades the cartilage and eventually the bone in RA; composed of A and B synoviocytes and plasma cells.
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What are two key cytokines responsible for inflammation in RA?
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IL1 and TNF Alpha
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What do activated T cells secrete that leads to osteoclastogenesis?
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OPGL (RANKL)
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Do macrophages secrete IL4 and IL10?
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No. In fact they actually suppress macrophage activation and pro-inflammatory cytokine production.
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