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13 Cards in this Set

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What are three examples of "addictions" that can increase bone catabolism?
1. caffeine
2. tobacco
3. alcohol
What is the maximum recommended amount for caffeine intake per day?
3 drinks/day
What is the maximum recommended amount for alcohol intake per day?
2 alcoholic beverages/day
Are thin or overweight people more susceptible to bone catabolism?
Thin.
Low BMI and weight loss are factors that increase bone catabolism.
What are the 2 critical nutritional components for healthy bones?
Vitamin D
Calcium
What is calcium's role in bone formation?
It is essential for bone mineralization.
(hydroxyapatite is made of calcium, phosphate, OH)
What is the vitamin formed by cholesterol and UV light?
Vitamin D3 (cholecalciferol)
What happens to cholecalciferol?
It is oxidized in the liver to 25-dihydroxycholecalciferol
What happens to 25-dihydroxycholecalciferol?
It is oxidized in the kidney to
1,25-dihydroxycholecalciferol
aka: 1,25-(OH)2-D3
aka: calcitriol
What is calcitriol?
1. The most active metabolite of vitamin D3.
2. An important calcium regulating hormone
What is the action of calcitriol?
1. Stimulates a calcium binding protein - facilitating calcium transport in gut, bone, kidney.
2. Facilitates phosphate transport
How is production of calcitriol regulated?
1. low Ca/PO4 increases PTH, PTH activates kidney enzyme for calcitriol synthesis
2. high PO4 inhibits synthesis
How is one way (nutritionally) that you can get high phosphates (PO4)?
Drink a lot of pop.