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6 Cards in this Set
- Front
- Back
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Does estrogen increase bone formation or decrease bone resorption?
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Decrease bone resorption
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Osteoblasts have receptors for Estrogen. What effect does estrogen have on osteoblasts?
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Direct the synthesis of Osteoprotegerin (OPG) instead of RANKL
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Whats is the function of osteoprotegerin (OPG)?
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OPG is a similar structure to the receptor for RANKL (RANK), therefore when secreted it acts as a decoy receptor and prevents the interaction between RANKL and RANK (inhibits osteoclast maturation).
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What effect does estrogen have on GI absorption of calcium?
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Increases calcium absorption
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True or False:
Estradiol levels are increased by liver disease? |
True
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In addition to indirect down regulation of osteoclast activity (through OPG), estrogen has what other effect on osteoclasts?
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Estrogen has a PRO-apoptotic effect on osteoclasts and an ANTI-apoptotic effect on osteoblasts.
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