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6 Cards in this Set
- Front
- Back
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What are glucocorticoids?
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A class of steroid hormones that bind with the ubiquitous glucocorticoid receptor.
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What is an example of a glucocorticoid?
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Cortisol.
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What are two ways that cortisol can affect bone remodelling?
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Decrease bone formation.
Increase bone resorption. |
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How does glucocorticoids decrease bone formation? (4 ways)
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1. Inhibit osteoblasts
2. Decrease intestinal Ca absorption. 3. Increase renal Ca excretion 4. Decrease collagen formation. |
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What are 2 ways that glucocorticoids increase bone resorption?
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1. Stimulate production of osteoclasts.
2. Increse secretion of PTH. |
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Is glucocorticoid induced fracture risk reversible with discontinuation of exogenous hormone?
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Yes. Fracture risk declines rapidly in first year off steroids.
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