Msk - Skin Disorders

Front 1

Warts

Back 1

verrucae

Front 2

soft, tan-colored, cauliflower like lesions

Back 2

warts - verrucae

Front 3

epidermal hyperplasia, hyperkeratosis, koilocytosis

Back 3

verrucae

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what does HPV cause on hands and genitals

Back 4

hands: verruca vulgaris -- genitals: condyloma acuminatum

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common mole

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nevocellular nevus

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intensely pruritic wheals that form after mast cell degranulation

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urticaria - hives

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freckle

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ephelis

Front 8

what is different about melanocytes / melanin pigment in freckles

Back 8

ephelis, norm number of melanocytes, increased melanin

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typer IV hypersensitivity rxn that follows exposure to allergen, lesions occur at site of contact

Back 9

allergic contact dermatitis

Front 10

pruritic eruption, skin flexures

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atopic dermatitis (eczema) -- assoc with other atopic diseases (asthma, allergic rhinitis)

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papules and plaques with silvery scaling, knees / elbows

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psoriasis

Front 12

acanthosis with parakeratotic scaling, increased stratum spinosum, decreased stratum granulosum

Back 12

psoriasis

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what is Auspitz sign, and where is it seen?

Back 13

bleeding spots when scales are scraped (in psoriasis)

Front 14

can be associated with nail pitting

Back 14

psoriasis

Front 15

flat, greasy, pigmented squamous epithelial proliferation with keratin-filled cysts

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seborrheic keratosis

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looks "pasted on"

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seborrheic keratosis

Front 17

where do seborrheic keratosis lesions occur

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head, trunk, extremities

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common benign lesion of older people

Back 18

seborrheic keratosis

Front 19

what is the sign of Leser-Trelat?

Back 19

sudden appearance of seborrheic keratoses indicating underlying malignancy (GI / lymphoid)

Front 20

normal melanocyte number, decreased melanin production

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albinism

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enzyme deficiency in albinism

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tyrosinase

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embryology of albinism

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failure of neural crest cell migration during development

Front 23

irregular areas of complete depigmentation

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vitiligo

Front 24

what is the problem with melanocytes in vitiligo?

Back 24

decreased number (probably autoimmune destruction)

Front 25

hyperpigmentation associated with pregnancy or OCP use

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melasma ("mask of pregnancy")

Front 26

superficial skin infection, highly contagious, honey colored crusting

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impetigo (s. aureus, s. pyogenes)

Front 27

what organisms cause impetigo?

Back 27

s. aureus or s. pyogenes

Front 28

acute, painful infection of dermis and subcut tissues

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cellulitis (s. pyogenes or s. aureus)

Front 29

what organisms cause cellulitis?

Back 29

s. pyogenes or s. aureus

Front 30

deeper tissue injury, crepitus

Back 30

necrotizing fasciitis

Front 31

what causes crepitus?

Back 31

methane and CO2 production from "flesh eating bacteria" (seen in necrotizing fasciitis)

Front 32

what organisms cause necrotizing fasciitis?

Back 32

anaerobic bacteria and s. pyogenes

Front 33

exotoxin destroys keratinocyte attachments in stratum granulosum only

Back 33

staph scalded skin syndrome

Front 34

fever, generalized erythematous rash with sloughing of upper layers of dermis (newborns and children)

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staph scalded skin syndrome

Front 35

white, painless plaques on tongue that can't e scraped off (EBV mediated)

Back 35

hairy leukoplakia

Front 36

who get's hairy leukoplakia

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HIV patients

Front 37

what organism is involved in hairy leukoplakia?

Back 37

EBV

Front 38

potentially fatal autoimmune skin disorder with IgG antibodies against desmosomes

Back 38

pemphigus vulgaris

Front 39

antibodies around cells of epidermis in reticular / netlike pattern

Back 39

pemphigus vulgaris

Front 40

acantholysis -- intraepidermal bullae involving skin and oral mucosa

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pemphigus vulgaris

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Nikolsky's sign

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eparation of epidermis upon manual stroking of skin (see in pemphigus vulgaris)

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antibody in pemphigus vulgaris

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anti-desmosome IgG

Front 43

where are bullae located in pemphigus vulgaris

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skin, oral mucosa, scalp, neck, face, trunk

Front 44

autoimmune disorder with Abs against hemidesmosomes

Back 44

bullous pemphigoid

Front 45

what is the antibody in bullous pemphigoid?

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anti-hemidesmosome

Front 46

what type of IF in bullous pemphigoid?

Back 46

linear (hemidesmosomes on basement membrane)

Front 47

eosinophils within blisters

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bullous pemphigoid

Front 48

affects skin but spares oral mucosa

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bullous pemphigoid

Front 49

negative Nikolsky's

Back 49

bullous pemphigoid

Front 50

pruritic papules and vesicles, IgA at tips of dermal papillae

Back 50

dermatitis herpetiformis (seen in Celiac)

Front 51

what rash is seen in celiac disease

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dermatitis herpetiformis

Front 52

associated with infections, drugs, cancers, autoimmune diseases -- multiple types of lesions (macules, papules, vesicles, target lesions)

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erythema multiforme

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red papules with a pale central area

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target lesions (some of the lesions seen in erythema multiforme)

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what causes erythema multiforme?

Back 54

infections (M. pneumo, HSV), drugs (sulfa, b-lactams, phenytoin), cancer, autoimmune

Front 55

fever, bulla formation, necrosis, sloughing of skin and high mortality rate

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stevens-johnson syndrome

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toxic epidermal necrolysis

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more severe form of stevens-johnson syndrome --

(SJS: fever, bulla formation, necrosis, sloughing of skin and high mortality rate)

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usually associated with adverse drug reaction

Back 57

stevens-johnson syndrome

Front 58

pruritic, purple, polygonal papules, sawtooth infiltrate of lymphocytes at dermal / epidermal junction

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lichen planus (assoc with Hep C)

Front 59

what skin disorder is associated with Hep C?

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lichen planus (pruritic, purple, polygonal papules, sawtooth infiltrate of lymphocytes at dermal / epidermal junction)

Front 60

premalignant lesions caused by sun exposure

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actinic keratosis

Front 61

small, rough, erythematous or brownish papules -- "cutaneous horn"

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actinic keratosis

Front 62

risk of carcinoma is proportional to epithelial dysplasia in what disorder?

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actinic keratosis

Front 63

hyperplasia of stratum spinosum, assoc with hyperinsulinemia, visceral malignancy

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acanthosis nigricans

Front 64

inflammatory lesions of subcut fat, usually on anterior shins

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erythema nodosum

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conditions associated with erythema nodosum

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(inflamm lesions of subcut fat on anterior shins) -- sarcoid, coccidioidomycosis, histoplasmosis, TB, leprosy, strep infections

Front 66

"herald patch" followed days later by "christmas tree" distribution, multiple papular eruptions, remit spontaneously

Back 66

pityriasis rosea

Front 67

first few weeks of life, grows rapidly, regresses spontaneously at 5-8 years

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strawberry hemangioma

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appears in 30s-40s and does not regress

Back 68

cherry hemangioma