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11 Cards in this Set

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acute attacks of gout
Colchicine
Indomethacin
suppress leukocyte activation
Colchicine
Indomethacin
*Used in place of Colchicine for acute attacks b/c less diarrhea
indomethacin
*decr Total body urate pool (even though plasma urate may not fall much)
probenacid
decr Urate pool & plasma pool
allopurinol
colchicine
MOA:
*Binds intracellular protein tubulin to prevent polymerization into microtubules (Katherine: thus, preventing mitosis)
*Inhibits leukocyte migration & phagocytosis

Tx:
*Suppresses leukocyte activation
*Acute attacks

SE:
*Diarrhea & abdominal pain
*Alopecia (hair loss); makes sense b/c inhibiting mitosis (↓hair cells)
*Bone marrow depression; makes sense b/c inhibiting mitosis (↓BM cells)
*Myopathy
indomethacin
MOA:
*NSAIDthus prevention of transcription of genes for many mediators of inflammation
*Inhibits *PG synthesis to prevent phagocytosis of urate crystals by synoviocytes & macrophages

Tx:
*Suppresses leukocyte activation
*Acute attacks
*Used in place of Colchicine for acute attacks b/c less diarrhea
probenacid
MOA:
*decr Total body urate pool (even though plasma urate may not fall much)

PE:
*Reabsorption of tophaceous urate deposits
==>less Joint inflam
==>Bone remineralization (b/c no more crystals causing inflamm)

Tx:
*incr Renal urate excretion (and ↓ reabsorption)
*Prophylaxis of recurrent episodes

SE:
*Renal urate stones  can be reduced by making the urine alkaline w/ acetazolamide, etc
*GI irritation
PE:
*Reabsorption of tophaceous urate deposits
==>less Joint inflam
==>Bone remineralization (b/c no more crystals causing inflamm)
probenacid and allopurinol
*Prophylaxis of recurrent episodes
probenacid
allopurinol
allopurinol
MOA:
*Inhibits xanthine oxidase
*decr Urate pool & plasma pool
*incr Conc of more water-soluble compounds hypoxanthine & xanthine (b/c these are the reactants of the chemical rxn that uses xanthine oxidase)

PE: *Reabsorption of tophaceous urate deposits
*less Joint inflam
*Bone remineralization (b/c no more crystals causing inflamm)

Tx:*decr urate production
*Prophylaxis of recurrent episodes

SE: GI irritation