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11 Cards in this Set
- Front
- Back
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acute attacks of gout
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Colchicine
Indomethacin |
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suppress leukocyte activation
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Colchicine
Indomethacin |
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*Used in place of Colchicine for acute attacks b/c less diarrhea
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indomethacin
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*decr Total body urate pool (even though plasma urate may not fall much)
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probenacid
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decr Urate pool & plasma pool
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allopurinol
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colchicine
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MOA:
*Binds intracellular protein tubulin to prevent polymerization into microtubules (Katherine: thus, preventing mitosis) *Inhibits leukocyte migration & phagocytosis Tx: *Suppresses leukocyte activation *Acute attacks SE: *Diarrhea & abdominal pain *Alopecia (hair loss); makes sense b/c inhibiting mitosis (↓hair cells) *Bone marrow depression; makes sense b/c inhibiting mitosis (↓BM cells) *Myopathy |
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indomethacin
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MOA:
*NSAIDthus prevention of transcription of genes for many mediators of inflammation *Inhibits *PG synthesis to prevent phagocytosis of urate crystals by synoviocytes & macrophages Tx: *Suppresses leukocyte activation *Acute attacks *Used in place of Colchicine for acute attacks b/c less diarrhea |
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probenacid
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MOA:
*decr Total body urate pool (even though plasma urate may not fall much) PE: *Reabsorption of tophaceous urate deposits ==>less Joint inflam ==>Bone remineralization (b/c no more crystals causing inflamm) Tx: *incr Renal urate excretion (and ↓ reabsorption) *Prophylaxis of recurrent episodes SE: *Renal urate stones can be reduced by making the urine alkaline w/ acetazolamide, etc *GI irritation |
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PE:
*Reabsorption of tophaceous urate deposits ==>less Joint inflam ==>Bone remineralization (b/c no more crystals causing inflamm) |
probenacid and allopurinol
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*Prophylaxis of recurrent episodes
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probenacid
allopurinol |
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allopurinol
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MOA:
*Inhibits xanthine oxidase *decr Urate pool & plasma pool *incr Conc of more water-soluble compounds hypoxanthine & xanthine (b/c these are the reactants of the chemical rxn that uses xanthine oxidase) PE: *Reabsorption of tophaceous urate deposits *less Joint inflam *Bone remineralization (b/c no more crystals causing inflamm) Tx:*decr urate production *Prophylaxis of recurrent episodes SE: GI irritation |
