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13 Cards in this Set

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Another name for Padget Disease
Osteitis Deformans
Most common skeletal distribution of Padget Disease?
Calvarium, spine (lumbosacral), and pelvis
Padget disease is best diagnosed with what modality?
Radiographs
Large, well-defined lytic areas in the skull
Osteoporosis circumscripta (Padget disease)
Best diagnostic clue of Padget disease?
Subchondral location with advancing wedge/V shape "blade of grass/candle flame"
DDx of ivory vertebral body
Blastic mets (BR, prostate, GI adeno, carcinoid)
Lymphoma
Padget disease
Chronic infection
Chordoma
Radiographic findings of Paget Disease?
Mixed sclerosis and lucency
Trabecular and cortical thickening (along the lines of stress)
Bone enlargement
Skull-cotton wool (spares face)
Vert bodies-picture frame; ivory vert body; may involve post elements
What is the key differentiator on MR of normal Padget's vs. sacomatous transformation?
Maintained yellow marrow on T1 (speckles of white). Tumor doesn't spare the marrow.
DDx of vertebra plana?
Langerhans cell histiocytosis (EG)
Padget disease
What are the signs of sarcomatous transformation in Paget disease?
Bone destruction predominates
Cortical involvement with ST mass
Persistent non-healing fx
Bone scan: photopenic area
MR T1: mass-like marrow replacement
MR T2: high intensity focal mass
DDx of trabecular thickening
Hemangioma (spine)
Chronic infection
Padget disease
Osteomalacia
Fluorosis
DDx of polyostotic lesions
CRF (hyperparathyroidism)
Langerhans cell histiocytosis
Metastasis
Paget disease
Fibrous dysplasia
Lymphoma
What are the complications of Padget disease?
Fractures
Osseous deformity
Neurologic sxs
Arthritis
Neoplasm