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13 Cards in this Set
- Front
- Back
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Another name for Padget Disease
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Osteitis Deformans
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Most common skeletal distribution of Padget Disease?
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Calvarium, spine (lumbosacral), and pelvis
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Padget disease is best diagnosed with what modality?
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Radiographs
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Large, well-defined lytic areas in the skull
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Osteoporosis circumscripta (Padget disease)
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Best diagnostic clue of Padget disease?
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Subchondral location with advancing wedge/V shape "blade of grass/candle flame"
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DDx of ivory vertebral body
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Blastic mets (BR, prostate, GI adeno, carcinoid)
Lymphoma Padget disease Chronic infection Chordoma |
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Radiographic findings of Paget Disease?
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Mixed sclerosis and lucency
Trabecular and cortical thickening (along the lines of stress) Bone enlargement Skull-cotton wool (spares face) Vert bodies-picture frame; ivory vert body; may involve post elements |
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What is the key differentiator on MR of normal Padget's vs. sacomatous transformation?
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Maintained yellow marrow on T1 (speckles of white). Tumor doesn't spare the marrow.
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DDx of vertebra plana?
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Langerhans cell histiocytosis (EG)
Padget disease |
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What are the signs of sarcomatous transformation in Paget disease?
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Bone destruction predominates
Cortical involvement with ST mass Persistent non-healing fx Bone scan: photopenic area MR T1: mass-like marrow replacement MR T2: high intensity focal mass |
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DDx of trabecular thickening
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Hemangioma (spine)
Chronic infection Padget disease Osteomalacia Fluorosis |
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DDx of polyostotic lesions
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CRF (hyperparathyroidism)
Langerhans cell histiocytosis Metastasis Paget disease Fibrous dysplasia Lymphoma |
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What are the complications of Padget disease?
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Fractures
Osseous deformity Neurologic sxs Arthritis Neoplasm |
