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26 Cards in this Set
- Front
- Back
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Ab to SCL-70
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diffuse systemic sclerosis
auto-ab to topoisomerase |
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anti-centromere antibodies
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limited cutaneous sclerosis
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systemic sclerosis differential dx
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raynaud's
esophageal reflux sclerodactyly |
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Cutaneous and visceral fibrosis
Vascular Dysfunction Raynaud’s phenomenon Immune activation |
effects
affects heart & lungs due to the visceral fibrosis. |
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affects visceral systems:
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GI, heart, lungs
due to fibrosis of the viscera! |
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Triphasic vascular response
Pallor Cyanosis Reactive hyperemia |
raynaud's
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where do you see raynaud's?
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SLE
Dermatomyositis Rheumatoid arthritis (also) Vibrating instruments, jack hammers and chain saws B-blockers, ergots Cryoglobulinemia Hyperviscosity syndrome |
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Severe heartburn
Telangiectasia Antinuclear antibodies |
these indicate a risk for devloping systemic sclerosis (not dx of!)
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treatment of raynaud's phenomenon
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calcium channel blocker
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treat organ sx of systemic sclerosis
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GI: proton pumpblocker (omeprazole), or histamine2 receptor antagonist
renal: corticosteroid therapy (also for inflammatory arthritis) |
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Progressive symmetrical proximal weakness
Elevation of muscle enzymes Muscle histologic features Mononuclear inflammatory cell infiltrates Muscle fiber necrosis Characteristic electromyographic abnormalities |
idiopathic inflammatory myopathies
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anti-jo (anti-synthetase)
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assoc w inflammatory myositis
both polymyositis and dermatomyositis |
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extra-muscular manifestations of myositis
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pulmonary, cardiac, GI,
arthritis (non-erosive--unlike RA which is erosive, small joint, symmetrical) |
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age of onset: myositis
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bimodal distribution
peak btw age 10-15 age 40-60 myositis |
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age of onset: systemic sclerosis
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4th to 7th decade (50 to 80)
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Associated with:
Hashimoto’s thyroiditis Myasthenia gravis Primary biliary cirrhosis Connective tissue diseases |
myositis
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Onset is insidious over months
Proximal muscle weakness |
polymyositis
(Rare, fulminant with proximal and distal weakness) |
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More indolent onset
Both proximal and distal weakness |
inclusion body myositis
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Characteristic skin eruption usually preceding the development of myositis
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dermatomyositis
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Erythematous rash
V shape on the anterior chest (shawl sign) |
dermatomyositis
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Grottron’s lesions (scaly rash over hands)
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dermatomyositis
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shawl
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dermatomyositis
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relationship with malignant disease
Lung Breast Prostate Colon Ovary |
dermatomyositis
polymyositis |
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dx of myositis?
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CPK and Aldolase are elevated
confirm w/ muscle biopsy |
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tx of myositis?
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Treat with steroids until the CPK falls or muscle strength has improved
(corticosteroids) 1/3 to ¼ may require additional immunosuppressive agents |
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can't hold hairdryer
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polymyositis
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