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41 Cards in this Set
- Front
- Back
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Ab to ds DNA
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Systemic Lupus Erythematosus
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Ab Anti-Smith
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Systemic Lupus Erythematosus
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Ab Anti-histone
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Drug Induced Lupus
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Null alleles
Genetic deficiency of C1q, C2, C4 [complement] |
strong risk factors for Lupus
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Immune complex deposition in target organs
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Systemic Lupus Erythematosus
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Impaired clearance of immune complexes
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Systemic Lupus Erythematosus
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Defective clearance of apoptotic cells
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Systemic Lupus Erythematosus
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Lupus Nephritis:
Ab directed throughout, or Basement Mb? |
Everywhere
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Nephritis:
Ab directed to basement Mb? |
Goodpasture's
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Hydralazine
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drug-induced lupus
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U1-RNP ab
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Mixed Connective Tissue Disease
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Recurrent fetal loss
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Anti-phospholipid Syndrome
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Livedo Reticularis
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Anti-phospholipid Syndrome
affects limbs mostly; sometimes torso |
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biologic false positive serologic test for syphilis
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Anti-phospholipid Syndrome
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procainamide
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drug-induced lupus
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anti-cardiolipin
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Anti-phospholipid Syndrome
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anti-beta 2 glycoprotein I
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Anti-phospholipid Syndrome
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anti-phosphatidylserine
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Anti-phospholipid Syndrome
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thrombosis in both arteries and veins
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Anti-phospholipid Syndrome
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thrombosis in both arteries and veins, preclampsia, pre-term delivery, miscarriage, stillbirth
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Anti-phospholipid Syndrome
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Therapy for Anti-phospholipid Syndrome
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heparin or LMW heparin
warfarin |
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in the body: coagulates, forms thrombi
in the lab: does not coagulate due to ab |
Anti-phospholipid Syndrome
In vivo, it’s actually damaging the endothelium so it’s causing micro-thrombi to form. Testing it in the lab, you’ll decrease the ability to clot, but in the body, it promotes blood. |
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Tx for Anti-phospholipid Syndrome
during pregnancy |
WARFARIN IS TERATOGENIC!!
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Anti-proteinase 3 Ab
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Vasculitis
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Anti-myeloperoxidase ab
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Vasculitis
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Vasculitis
Large arteries (ex: aortic arch) |
1) Takayasu
2) Giant Cell Arteritis 3) Behcet's |
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Young women
consitutional problems: fever, weight loss, arthritis pulseless High sed rate |
Takayasu
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mucocutaneous ulcers (excl Herpes I)
uveitis venous thrombi |
behcet's
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Polyarteritis nodosa
Rheumatoid vasculitis Buerger’s disease Primary central nervous system angiitis Kawasaki |
vasculitis:
medium size arteries |
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> 50 years old; high sedimentation rate
Polymyalgia rheumatica Risk of blindness, heart attack, stroke Need for urgent therapy |
giant cell arteritis
large artery vasculitis enlarged artery in forehead! |
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Polyarteritis nodosa
Rheumatoid vasculitis Buerger’s disease Primary central nervous system angiitis Kawasaki |
medium size artery
vasculitis |
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Terminal arteries. Will cause gangrene on the tips of the fingers, tips of the toes. Highly assoc with smoking!!!
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buerger's
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Mucocutaneous ulcers (oral, genital, ileum, cecal)
Herpes simplex excluded (Very painful!) Ocular inflammation - retinal vasculitis [uveitis] Aneurysms Venous thromboses Arthritis Pathergy |
behcet's
large artery vasculitis |
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Leukocytoclastic (cutaneous) vasculitis
Henoch-Schoenlein; cryoglobulinemia; |
small-sized artery
vasculitis immune-complex mediated |
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Wegener’s; Churg Strauss; microscopic polyangiitis
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small-sized artery
vasculitis ANCA associated |
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lumpy glomerulonephritis
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ANCA = anti-nuclear cytoplasmic antibody
Wegner's |
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ab against lung and kidney
basement mb hemoptussis, hemopturia |
goodpasture's
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ab against lung and kidney and sinusitis
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wegner's
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Anti-thyroid microsomal peroxidase Ab
HYPERthyroid >> HYPOthyroid |
hashimoto's
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Anti-proteinase 3 Ab
ANCA |
Wegener's
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Anti-myeloperoxidase Ab
ANCA |
non-specific
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