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43 Cards in this Set
- Front
- Back
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clonidine
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"<b>Mechanism of Action</b>: <u>alpha-2</u> adrenergic receptor <u>agonist</u>
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alpha methyldopa
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"<b>Mechanism of Action</b>: <u>alpha-2</u> adrenergic receptor <u>agonist</u>
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trimethaphan
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"<u>Sympathetic Inhibitor: Ganglionic Blockade</u>
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riserpine
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"<u>Sympathetic inhibitor: presynaptic catecholamine depletion</u>
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phenoxybenzamine
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"<b>Mechanism of Action</b>: <b><u>Irreversible</u> </b><u>postsynaptic</u> <u>inhibitor</u> of <u>alpha1</u>- and <u>alph</u>a2- <u>adrenergic</u> <u>receptors</u> (binds covalently)<b>
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phentolamine
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"<b>Mechanism of Action</b>: <b><u>R</u><u>eversible</u> </b><u>postsynaptic</u> <u>inhibitor</u> of <u>alpha1</u>- and <u>alph</u>a2- <u>adrenergic</u> <u>receptors</u> (binds covalently)<b>
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tolazoline
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"<b>Mechanism of Action</b>: <b><u>Reversible</u> </b><u>postsynaptic</u> <u>inhibitor</u> of <u>alpha1</u>- and <u>alph</u>a2- <u>adrenergic</u> <u>receptors</u> (binds covalently)<b>
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prazosin (terazosin, doxazosin)
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"<b>Mechanism of Action</b>: Selective post-synaptic inhibitor of <u>alpha-1 adrenergic receptors</u>
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propranolol, nadolol
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"<b>Mechanism of Action</b>: <b><u>Non-selective beta-blocker</u></b> (blocks beta-1 and beta-2 adrenergic receptors post-synaptically; <u>reversible</u>)
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metoprolol
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"<b>Mechanism of Action</b>:""<b><u>Selective"" beta-blocker</u></b> (blocks beta-1 > beta-2 adrenergic receptors post-synaptically; <u>reversible</u>)
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carevediolol
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"<b>Mechanism of action</b>: <u>beta and alpha blocker (alpha-1, beta-1, beta-2)
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labetalol
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"<b>Mechanism of action</b>: <u>beta and alpha blocker (alpha-1, beta-1, beta-2)
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fenoldopam
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"<b>Mechanism of Action</b>:post-synaptic dopamine receptor agonist (<u>selective DA1 peripheral agonist)</u>
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erythropoietin (EPO)
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"<b>Mechanism of Action</b>: <u>promotes erythropoiesis</u> (hormone)<u>
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thiopental
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"<b>Mechanism of Action</b>: <u>GABA agonist IV anesthetic</u>.
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propofol
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"<b>Mechanism of Action</b>: <u>GABA agonist IV anesthetic</u>.
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etomidate
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"<b>Mechanism of Action</b>: <u>GABA agonist IV anesthetic</u>.
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ketamine
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"<b>Mechanism of Action</b>: <u>NMDA receptor blocker</u>
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dexmedetomidine
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"<b>Mechanism of Action</b>: <u>central alpha-2 adrenergic agonist</u>
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remifentanil
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"<b>Mechanism of Action</b>: opiod receptor agonist
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halothane
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"<b>Mechanism of Action</b>: <u>Potent, volatile inhaled anesthetic</u>. Alkane.
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isoflurane
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"<b>Mechanism of Action</b>: <u>Potent, volatile inhaled anesthetic</u>. Ether.
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sevoflurane
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"<b>Mechanism of Action</b>: <u>Potent, volatile inhaled anesthetic</u>. Ether.
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desflurane
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"<b>Mechanism of Action</b>: <u>Potent, volatile inhaled anesthetic</u>. Ether.
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nitrous oxide (N2O)
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"<b>Mechanism of Action</b>: <u>Potent, volatile inhaled anesthetic</u>. Gas.
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phenobarbital, primidone
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"<b>Mechanism of Action</b>: <u>barbituate</u> anticonvulsants
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phenytoin
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"<b>Mechanism of Action</b>: Anticonvulsant, blocks <u>rapidly opening Na channels</u>
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carbamazepine
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"<b>Mechanism of Action</b>: Anticonvulsant, blocks <u>rapidly opening Na channels</u>
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valproic acid
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"<b>Mechanism of Action</b>: Anticonvulsant, blocks <u>rapidly opening Na channels</u>, <u>enhances GABA / BZ receptors</u>, may have other mechanisms?
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lamotrigine
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"<b>Mechanism of Action</b>: Anticonvulsant, blocks <u>Na channels associated with pre-synaptic glutamate release</u>
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levetiracetam
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"<b>Mechanism of Action</b>: <u>Anticonvulsant</u>, binds <u>SV2A vesicle protein</u> on synaptic vesicles
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topiramate
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"<b>Mechanism of Action</b>: <u>Anticonvulsant</u>, blocks <u>AMPA glutamate receptors</u>
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ethosuxamide
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"<b>Mechanism of Action</b>: <u>anticonvulsant</u>, blocks <u>voltage-dependent Ca channels</u>
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lorazepam, diazepam
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"<b>Mechanism of Action</b>: <u>benzodiazepine anticonvulsants</u>
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L-DOPA
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"<b>Mechanism of Action</b>: <u>Dopamine receptor agonist </u>(via DA, active <u>metabolite</u>)
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sinemet (L-DOPA + carbidopa)
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"<b>Mechanism of Action</b>: L-DOPA: <u>Dopamine receptor agonist </u>(via DA, active <u>metabolite</u>); <u>carbidopa</u> is a <u>peripheral AADC inhibitor</u>
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entacapone
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"<b>Mechanism of Action: </b><u>COMT inhibitor</u>.
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selegiline (edepryl)
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"<b>Mechanism of Action</b>: <u>MAO-inhibitor</u>, for <u>Parkinson Disease</u>
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rasagaline (Azilect)
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"MAO-B inhibitor: like selegiline, but <u>once-daily</u> (longer duration of action)<u>
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pramipexole (Mirapex); riponerole (Requip)
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"<b>Mechanism of Action</b>:<u>Non-ergot</u> <u>DA receptor agonists</u> (directly stimulate DA receptors). For <u>Parkinson Disease</u><b>
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benztropine (Cogentin), trihexyphenidyl (Artane)
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"<b>Mechanism of Action: </b><u>Anti-cholinergic</u> agents (anti-PD)
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amantadine (Symmetrel)
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"<b>Mechanism of Action</b>: anti-Parkinson Disease agent, multiple effects (poorly understood)
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Clonidine
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<b>Mechanism of Action</b>: <u>alpha-2</u> adrenergic receptor <u>agonist</u>
<b>Effects</b>:<u>Decreases sympathetic outflow</u> pre-synaptically (takes advantage of feedback mechanism to <u>inhibit AC</u>). <u>Decreases SVR, venous return, and CO</u><b> Indications</b>: Class-wide: <u>Hypertension</u>. Clonidine-specific: analgesia with <u>cancer pain,</u> suppresion of <u>opiod/opiate withdrawal</u><b> Administration</b>: Oral, predictable onset & duration but multiple daily doses needed. Also <u>topical patch</u> (1 wk duration)<b> Toxicity</b>: Class-wide: <u>sedation, orthostatic hypotension, erectile dysfunction</u>. Clonidine-specific: <u>bradycardia</u>, can get <u>rebound hypertension</u> on abupt discontinuation |
