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29 Cards in this Set
- Front
- Back
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Which arthritis does NOT involve the KIP or thoracolumbar spine
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RA
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RA's key genetic marker for
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HLA-DR4
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When does RA commonly remint?
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pregnancy
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What are the tumor -like attributes of AR? (2)
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1) neovascularization
2) infiltration of synovium with lymphocytes taht attach to and degrade teh cartilage and bony margins of the joint (ongoing CD4+ T-cell response -> releases cytokines that mature monocytes tinto synovial macrophages adn osteaoclasts) |
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___ derived cytokines may be the most important type in RA
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Th-17 (release RANK ligand)
Th-1 dreived cytokines (TNF, IL-12) also important |
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TNF alpha antibodies =
TNF alpha soluble receptor = |
TNF alpha antibodies =
infliximab TNF alpha soluble receptor = etanercept |
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outopouching of the synovium caused by weakneess in the joint capsule, especially posteriorly in the popliteal fossa
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Baker's cyst - swellig of calf
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long-standing severe RA with splenomegaly, lymphadenopathy and neutropenia
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Felty's syn
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RF is produced by ____ and present in ____ of the RA patients at the time of dx
also sen in what other dz's (3) |
plasma cells
2/3 1)lupus 2)primary SS 3)endocardidtis |
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Name lab find to fallow to see how RA is progressing?
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C Reactive Protein
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Ab highly specific for RA
exception? |
anti-CCP (cyclic citrulinated peptide)
exption is in psoriatic arthritis where it is found in 5-10% patients |
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2 enviromental predisposisng factors for SLE?
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1) sun exposure
2) sex hormones (estrogen replacement can acelerate the progression of SLE) |
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deficiencies in what proteins are assoicated with SLE?
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early compoenents fothe classical pathway of complement activation (C4a, C2, C1q)
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Ab found for SLE? (5)
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1) ANA - nonspecific
2) Anti-ds DNA - correlate with developemnt of renal disaae or glomerular nephritis 3) Anti-Smith (SM) - highly specific 4)Ab to nuclear histones - DRUGINDUCED SLE 5) Anti-phospholipid (APL) - not specific but correlate with 1)predisposition to thrombosis 2)low platelet count 3)osteonecrosis |
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most major cause fo mortality in women iwith lupis?
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premature CVD
..patiens arent dying of lupus |
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major predictor of the progression of Lupus nephritis to end stage renal disease
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Blood Pressure
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SLE ass with what heart complication?..Ab?
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Libman-Sacks Endocadrditis (nonbacterial, usually affects mitral valve; can cause stroke syn as emboli go to the brain)
ass with Anti-Phospholipid Ab (APA) |
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main pathogenic mech for SS?
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infiltration of exocrine galnd by lymphoytes (usually CD4_ T cells)
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SS genetically correlated with?
Ab? |
HLA-DR3
SSA Ab |
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Primary SS commonly affects who
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females in their child-bearing years
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Most common renal complication with SS
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DISTAL tubular acidosis (ass iwht kidney stones, nephrocalcinosis & hypokalemia)
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key hematologic hallmark of SS
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hypergammaglobulinemia (pt has lots of hyperactive B cells)
therefore UP risk of LYMPHOMA of B cell origin |
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Major Ab ass with SS (3)
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1)ANA
2)Anti-SSA (Ro) 3)Anti-SSB (La) |
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inflammatory myopathy exclusively in pt over age 50
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Inclusion Body Myositis
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___ Ab ass with subtype fo poly myositis that features?
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Anti Jo-1
lung dz (esp PULMONARY FIBROSIS) |
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MC site of osteoarthiritis
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carpal-metacarpal (CMC) joint of thumb
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why are pst-menopausal women more susceptible to gout?
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estrogen ahs a uricosuric effect, helping women excrete uric acid in their urine
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gout is esp ass with what syndrome? why?
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Lesch-Nyhan Syn - complete deficeincy fo HGPRT
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strongest risk factor for pseudogout (aka CPPD deposition dz)
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age
pseudogout has a AD inheritance pattern |
