Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
|
Myotonic Dystrophy
|
*Common
*AD inheritance *Mutation leads to CTG repeats in protein kinase *Wasted extremities, frontal alopecia *Myotonia-sustained m. contraction *Histological triad: selective T1 atrophy; internal nuclei; ring fibers |
|
|
Polymyositis
|
*Peak onset in 35-40 yo
*Rapid onset *Generalized muscle weakness;fever, malaise, fatigue *^ESR, ^CK *T-cell mediated *Histology: lymphocytic invasion, MHC-1 abnormally expressed in m. |
|
|
Inclusion Body Myositis
|
*Peak onset in 50-70 yo
*Slowly progressive *Asymmetric weakness *Steroid resistant *Histology: nuclear inclusions, fiber necrosis/regeneration, rimmed vacuole |
|
|
McArdle's Disease
|
*AR inheritance
*Glycogen storage disease *Myophosphorylase deficiency *Histology: crescent blebs where glycogen deposited *Unable to form lactate |
|
|
CPT Deficiency
|
*AR inheritance
*Lipid storage disease *CPT II deficiency *M>F *Episodic, attacks follow exercise *Myalgia, myoglobinuria |
