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5 Cards in this Set

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Small Pox (variola virus): incubation period
- 7-17 days
- during incubation, virus replicates in the upper respiratory tract --> primary viremia --> seeds liver and spleen --> secondary viremia --> seeds skin --> classic eruption
Small Pox: initial symptoms
- fever up to 104
- malaise
- severe HA
- vomiting
- backache
Small Pox: rash pattern and distribution
- occurs 1-2 days after onset of fever
- begins on face --> spreads to extremities and trunk
- initially erythematous macules --> then papules, vesicles, and firm pustules --> crusts form at 8 or 9 days and persist for 3-4 weeks --> as crusts separate,

- (majority of lesions are observed on face and extremities, with lesser # on the trunk)
- all lesions are in a similar stage of development
Varicella: rash pattern and distribution
- lesions erupt initially on the trunk and later on the face and extremities
- lesions are erythematous papules that evolve into superficial vesicles, pustules, and crusts
- lesions are in varying stages of development
- by 7-10 days after infection, all lesions have crusted.
Sequele of Varicella vs. Smallpox
Varicella: permanent scars are rare, only when lesions had secondary infection

Smallpox: pts are left with significant scars, depigmentation