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16 Cards in this Set
- Front
- Back
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which subtype of MS affects more men than women?
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PPMS
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which cytokines are disproportionately increased in MS?
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inflammatory cytokines: IL-12, TNF, INF-gamma
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molecule responsible for "opening" BBB?
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MMP
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charactertistics of initial optic neuritis that increase risk for MS?
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young adult female with unilateral, painful, normal optic disc
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characteristics of transverse myelitis that increase risk for MS?
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assymetric sensory>motor deficit, a small lesion and no edema
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definition of MS relapse?
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new, or wosening of neurological symptom for at least 24 hrs w/o precipitant
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psedo-relapse?
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relapse of sx. with a precipitating factor
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which CSF chemokines increase with steroid tx.?
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CCL2 and CXCL10
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glatiramer MOA?
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increase anti-inflammatory Th2 cytokines and BDNF; no effect on MMP
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IFN MOA?
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down-regulates Th1 cytokines
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the most common and often worst sx. of MS?
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fatigue/lassitude
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uthoff's sign?
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increased fatigue with increase heat
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prokarin?
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transdermal histamine, caffeine, vit. B12
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4-aminopyridine MOA?
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centrally-acting K channel blocker used to treat sx. of fatigue in MS
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which type of drugs used to treat inability to store urine?
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anticholinergics
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typical walking pattern of person with MS?
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circumduction due to foot drop IN ADDITION to hip flexor weakness
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