Mrcp Part 1

Front 1

Autosomal Dominant Disorders

Back 1

Gilbert's disease, Osteogenesis imperfecta, Treacher collins syndrome, Tuberous sclerosis, Hereditary haemorrhagic telangiectasia, Hereditary elliptocytosis, Hereditary spherocytosis, Huntington's disease, Achondroplasia, Antithrombin III deficiency, Marfan's syndrome, Marble bone disease, Von willebrand disease, Idiopathic hypoparathyroidism, Neurofibromatosis, C1 esterase inhibitor deficiency, Ehlers-danlos syndrome, Peutz-jegher's syndrome, Polycystic kidney disease (adult), Protein C deficiency, Intestinal polyposis

Hint 1

GOT2H4A2M2 VINCE P3I

Front 2

Autosomal Recessive Disorders

Back 2

Phenylketonuria, Cystic fibrosis, Sickle cell disease, Homocystinuria, Albinism (oculocutaneous), Alkaptonuria, Galactosaemia, Gaucher's disease, Glycogen storage disease, Wilson's disease, Endemic goitrous cretinism, Bartter's syndrome, Xeroderma pigmentosum.

Hint 2

PC SHA2G3 WEB X

Front 3

X-Linked Dominant Disorders

Back 3

Von Willebrand's disease, X-linked hypophosphataemic Rickets

Hint 3

VWX Rickets

Front 4

X-linked Recessive Disorders

Back 4

Becker's muscular dystrophy, Hunter's syndrome, Testicular feminisation syndrome, Fabry's disease, red-green Colour blindness, G6PDD, Wiskcott-aldrich syndrome, Haemophilia A & B, Duchenne's Muscular Dystrophy

Hint 4

BeckHun Test Fab Colour Glue Whisk & Haem Douche

Front 5

Restriction Enzymes

Back 5

Hind III & EcoRI

Hint 5

Eco Helicopter

Front 6

Blotting

Back 6

NoRthern = RNA

Southern D = DNA

Western = protein

Hint 6

R

D

Pro-west

Front 7

Genomic Imprinting Disorders

Back 7

Beckwith-wiedemann syndrome, Angelman syndrome, prader Willi syndrome, myotonic dystrophy

Hint 7

Beckwith Angel Willy & Dystrophy

Front 8

Mitochondrial Disorders

Back 8

Kearn Sayre's, Leber's optic atrophy, MELAS, Progressive external ophthalmoplegia, MERRF

MELAS = Mitochondirial Myopathy, Encephalopathy, Lactic Acidosis, Stroke

MERRF = Myoclonic Epilepsy with Ragged Red Fibres

Hint 8

KS LoaM PeoM

Front 9

Oncogenes

Back 9

Ras (sporadic tumours, rhabdomyosarcomas)

C-myc (Burkitt's lymphoma)

N-myc (Neuroblastoma)

SRC (Sarcoma)

Fas ligands, Caspases = apoptosis

Bax, Bad, Bak = cell death

Bcl-2 = inhibits apoptosis by p53

Hint 9

Rasism like rabies is everywhere

See Mike Burke? No, Mike Neuro.

S_RC_ _ _

Fast Capsizes

B = Bad

BLoCk cell death

Front 10

Tumour Suppression Genes

Back 10

NF-1 (Neurofibromatosis)

BRCA-1 (Breast/Ovarian Ca)

Rb (Retinoblastoma)

VHL (von Hippel Lindau)

p53

Hint 10

NB RsVP

Front 11

Enzyme Deficiencies

Back 11

Gaucher's disease (Gluco-cerebro-cidase deficiency)

Tay Sachs Disease (Hexos-aminidase A deficency)

Niemann Pick Disease (Sphingo-myelinase deficiency)

Metachromatic Leukodystrophy (Aryl-sulphatase deficiency)

Hurler's syndrome (Iduronidase deficiency)

Hint 11

Gluco gauch

Sax Hex

Pick Spin Go

Metachrome Aryl

Hurler's ID

Front 12

Causes of Retinitis Pigmentosa

Back 12

Lawrence Moon Biedl syndrome, Friedrich's ataxia, Usher's disease, Refsum's disease, Kearn Sayre's syndrome, Alport's syndrome

Hint 12

LaMB FURKSA

Front 13

G Protein Receptors

Back 13

FSH, Adrenergic receptor, Retinal rhodopsin receptor, TSH, Muscarinic ACh receptor, ACTH, GABA receptors

Hint 13

FART MAG

Front 14

Diseases with G Protein Second Messenger Abnormalities

Back 14

McCune Albright syndrome, Pituitary Adenoma, Cholera, Albright's Hereditary Osteodystrophy

Hint 14

MA PA CAH

Front 15

TK Receptors

Back 15

VEGF

IGF-1

Insulin

PDGF

Epidermal Growth Factor

Macrophage colony stimulating factor

Hint 15

VI2PE MCSF

Front 16

X-linked Immunodeficiency

Back 16

SCID - severe combined immunodeficiency

Bruton's hypogammaglobulinaemia

Hint 16

X Brute Skid

Front 17

Prion Diseases

Back 17

CKD, Kuru, Scrapie (BSE)

Hint 17

KiCK & Scrape

Front 18

Drugs with Zero Order Kinetics

Back 18

Fluoxetine

Alcohol

Phenytoin

Hint 18

FAP

Front 19

Liver Enzyme Inducers

Back 19

Carbamazepine, Rifampicin, Alcohol, Phenytoin, Barbiturates, Sulphonylureas

Hint 19

CRAP BS

Front 20

Liver Enzyme Inhibitors

Back 20

Omeprazole, Amiodarone, Allopurinol, Ketoconazole, Disulfuram, Erythromycin, Valproate, Isoniazid, Ciprofloxacin, Cimetidine, Ethanol, Sulphonamides

Hint 20

OA2K DEVIC2ES

Front 21

Drugs that cause Lupus

Back 21

Chlorpromazine, Hydralazine, Isoniazide, Procainamide, Penicillamine, Sulfasalazine, Methyldopa, Quinidine

Hint 21

CHIP2S MQ

Front 22

Drugs that cause Gynaecomastia

Back 22

Nifedipine, Oestrogens, Digoxin, Spironolactone, Cimetidine, Verapamil

Hint 22

NODS CV

Front 23

Drugs that cause Galactorrhoea

Back 23

Metoclopramide, OCPs, Bromocriptine, Phenothiazines (Chlorpropramide, Thioridazine)

Hint 23

MOB P(CT)

Front 24

Drugs that cause SIADH

Back 24

Phenothiazines, SSRIs, Cyclophosphamide, Chlorpropramide, Carbamazepine, Clofibrate, Thiazides, TCAs, Vincristine, Vinblastine

Hint 24

PS C4T2V2

Front 25

Drugs that cause Hypercalcaemia

Back 25

Progesterone, Alkaline antacids, DES, Lithium, Estrogens, Thiazides

Hint 25

PADLET

Front 26

Drugs that cause Anticholinergic Syndrome

Back 26

TCAs, antihistamines, atropine

Front 27

Causes of Methaemoglobinaemia

Back 27

Prilocaine, Antimalarials, Nitrates (including food), Dapsone, Aniline dyes, Sulphonamides

Hint 27

PAN2DAS