Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
7 Cards in this Set
- Front
- Back
|
what are the myeloproliferative neoplasms?
|
chronic myeloid leukemia (CML)
polycythaemia vera (PV) essential thrombocytemia (ET) primary myelofibrosis (PMF) |
|
|
what is the incidence of AMM?
|
0.5/100'000
|
|
|
what is the median age at diagnosis in AMM?
|
65 years
|
|
|
what mutation is found in a significant proportion of MPN?
|
JAK2716F mutation
|
|
|
what is the JAK2 mutation?
|
gain of function mutation in the nonreceptor tyrosine kinase 2 with consecutive constitutive kinase activity
|
|
|
at what level of the development of hematologic cells does the JAK2 mutation occur?
|
at the level of a pluripotent stem cell originating myeloid and lymphoid cells
|
|
|
in what percentage is the JAK2 mutation found in the MPN?
|
PV nearly all
ET and PMF 50% |
