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25 Cards in this Set

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Shy Drager
Parkinson's with disfunctinal autonomic nervous system funtion
Familial or essential tics are aggravated by 1) and relieved by 2)
1) Caffeine
2) Ehtanol
Torsion dystonia is more common in this racial lineage
Ashkenazi jewish lineage
Two methods of break down for L-DOPA
Methylation (COMT)
Decarboxylation (DOPA)
Where caridopa works
In periphery to block decarboxylation of L-DOPA
Like carbidopa, these two drugs inhibit L-DOPA break down, but the act on COMT
Tolcapone
Entacapone
A few incidents of fatal hepatic necrosis with this drug
Tolcapone (COMT inhibitor)

Monitor liver enzyems every 2 weeks while using
Rare side effect of Tolcapone
Fatal Hepatic Necrosis
4 dopamine agonists
Bromocriptine
Pergolide
Pramipexole
Ropinirole

Last two are highly selective for D2 and more effective
Cardiac valve thickening
Associated with pergolide use (dop agonist)
Amantidine
Used for dyskinesias

Increases dopamine release from dopamine terminals
Anticholinergic drugs
Work to lower ACh effects but have typical side effects

Benztropine
Trihexiphenidyl
Selegiline
MAO-B Inhibitor

May have neuroprotective effect for 1-2 years, but it is falling in popularity
Antispasticity drugs
Baclofen
Benzodiazapines
Tizanidine
Baclofen
GABA-B agonist used for antispasticity
Tizanidine
antispasticity drug

alpha adronergic antagonist
Good neuroletpcis for treatment of psychosis and hyperkinesis
Clozapine better than typical AP's because no tardive dyskinesia
trihexyphenidyl
anticholinergic for parkinson's
metabolite of selegiline
amphetamine (undesirable)
5-hydroxytryptophan
useful for suppresing myclonus and helping ataxia
suppresses myoclonus
5-hydroxytryptophan
Tx for Tourett's
Use a neuoleptics with breaks to prevent tardive diskinesia
Tx for essential tremor
Propanolol
Mysoline
Benzodiazepines (or alcohol)
New Tx for dystonia
Clostridium Botulinum
Tx for movement disordres in Wilson's disease
Penicillamine (chelator)