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25 Cards in this Set
- Front
- Back
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Shy Drager
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Parkinson's with disfunctinal autonomic nervous system funtion
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Familial or essential tics are aggravated by 1) and relieved by 2)
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1) Caffeine
2) Ehtanol |
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Torsion dystonia is more common in this racial lineage
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Ashkenazi jewish lineage
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Two methods of break down for L-DOPA
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Methylation (COMT)
Decarboxylation (DOPA) |
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Where caridopa works
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In periphery to block decarboxylation of L-DOPA
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Like carbidopa, these two drugs inhibit L-DOPA break down, but the act on COMT
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Tolcapone
Entacapone |
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A few incidents of fatal hepatic necrosis with this drug
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Tolcapone (COMT inhibitor)
Monitor liver enzyems every 2 weeks while using |
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Rare side effect of Tolcapone
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Fatal Hepatic Necrosis
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4 dopamine agonists
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Bromocriptine
Pergolide Pramipexole Ropinirole Last two are highly selective for D2 and more effective |
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Cardiac valve thickening
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Associated with pergolide use (dop agonist)
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Amantidine
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Used for dyskinesias
Increases dopamine release from dopamine terminals |
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Anticholinergic drugs
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Work to lower ACh effects but have typical side effects
Benztropine Trihexiphenidyl |
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Selegiline
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MAO-B Inhibitor
May have neuroprotective effect for 1-2 years, but it is falling in popularity |
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Antispasticity drugs
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Baclofen
Benzodiazapines Tizanidine |
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Baclofen
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GABA-B agonist used for antispasticity
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Tizanidine
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antispasticity drug
alpha adronergic antagonist |
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Good neuroletpcis for treatment of psychosis and hyperkinesis
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Clozapine better than typical AP's because no tardive dyskinesia
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trihexyphenidyl
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anticholinergic for parkinson's
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metabolite of selegiline
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amphetamine (undesirable)
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5-hydroxytryptophan
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useful for suppresing myclonus and helping ataxia
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suppresses myoclonus
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5-hydroxytryptophan
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Tx for Tourett's
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Use a neuoleptics with breaks to prevent tardive diskinesia
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Tx for essential tremor
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Propanolol
Mysoline Benzodiazepines (or alcohol) |
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New Tx for dystonia
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Clostridium Botulinum
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Tx for movement disordres in Wilson's disease
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Penicillamine (chelator)
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